Epithelial to Mesenchymal transition (EMT) in cancer, a process permitting cancer cells to
become mobile and metastatic, has a signaling hardwire forged from development. Multiple …

Simple Summary The p53 protein is a transcription factor that initiates cell cycle arrest and
apoptosis and by this counteracts tumorigenesis. Because of its anti-proliferative activity …

Recent genetic studies have documented a pivotal growth-regulatory role played by the
Cullin 7 (CUL7) E3 ubiquitin ligase complex containing the Fbw8-substrate-targeting …

In the majority of human tumors, expression of the c-MYC oncogene becomes constitutive.
Here, we report that c-MYC directly regulates the expression of AP4 via CACGTG motifs in …

HPK1, a member of mammalian Ste20-like serine/threonine kinases, is lost in> 95%
pancreatic cancer through proteasome-mediated degradation. However, the mechanism of …

3-M syndrome, a primordial growth disorder, is associated with mutations in CUL7 and
OBSL1. Exome sequencing now identifies mutations in CCDC8 as a cause of 3-M …

3-M syndrome is an autosomal-recessive primordial growth disorder characterized by
significant intrauterine and postnatal growth restriction. Mutations in the CUL7 gene are …

Cullin family proteins function as scaffolds to form numerous E3 ubiquitin ligases with RING
proteins, adaptor proteins and substrate recognition receptors. These E3 ligases further …

Cancer cells depend heavily on glucose as both energy and biosynthesis sources and are
found to upregulate glucose transport and switch their main energy supply pathway from …

Cullin-RING ubiquitin ligases (CRLs) are responsible for the ubiquitination of many cellular
proteins, thereby targeting them for proteasomal degradation. In most cases the substrates …