Highlights•Adoption of segmentation models driven by user-friendly tools and
documentation.•Advancements in novel architectures are driven by the need for a truly …

Polarized cells rely on a polarized cytoskeleton to function. Yet, how cortical polarity cues
induce cytoskeleton polarization remains elusive. Here, we capitalized on recently …

Cells contain multiple condensates which spontaneously form due to the heterotypic
interactions between their components. Although the proteins and disordered region …

Recent advances in 3D pathology offer the ability to image orders of magnitude more tissue
than conventional pathology methods while also providing a volumetric context that is not …

Fluorescence microscopy is a fundamental tool in the life sciences, but the availability of
sophisticated equipment required to yield high-quality, quantitative data is a major …

Noonan syndrome patients harboring causative variants in LZTR1 are particularly at risk to
develop severe and early-onset hypertrophic cardiomyopathy. In this study, we investigate …

High-throughput imaging (HTI) generates complex imaging datasets from a large number of
experimental perturbations. Commercial HTI software programs for image analysis …

How complex 3D tissue shape emerges during animal development remains an important
open question in biology and biophysics. Here, we discover a mechanism for 3D epithelial …

Powerful, workflow-agnostic and interactive visualisation is essential for the ad hoc, human-
in-the-loop workflows typical of cryo-electron tomography (cryo-ET). While several tools exist …

Abstract Single Molecule Localisation Microscopy (SMLM) is becoming a widely used
technique in cell biology. After processing the images, the molecular localisations are …