Antibodies that gain specificity by a large insert encoding for an extra domain were
described for the first time in 2016. In malaria-exposed individuals, an exon deriving from the …

RNA processing includes post-transcriptional mechanisms controlling RNA quality and
quantity to ensure cellular homeostasis. Noncoding (nc) RNAs that are regulated by these …

Mitochondria serve as the cellular powerhouse, and their distinct DNA makes them a
prospective target for gene editing to treat genetic disorders. However, the impact of genome …

In metazoans mitochondrial DNA (mtDNA) or retrotransposon cDNA released to cytoplasm
are degraded by nucleases to prevent sterile inflammation. It remains unknown whether …

We developed a linear amplification–mediated high-throughput genome-wide translocation
sequencing method to profile Ig class-switch recombination (CSR) in human B cells in an …

Antibody repertoires are characterized by a vast diversity that endows antibodies with
potential to recognize multifarious target antigens with high affinities and specificities. The …

Formation of templated insertions at DNA double-strand breaks (DSBs) is very common in
cancer cells. The mechanisms and enzymes regulating these events are largely unknown …

In metazoans release of mitochondrial DNA or retrotransposon cDNA to cytoplasm can
cause sterile inflammation and disease 1. Cytoplasmic nucleases degrade these DNA …

The recent discovery of public antibodies targeting Plasmodium falciparum-encoded
repetitive interspersed families of polypeptides (RIFINs), which contain extracellular …

Formation of templated insertions at DNA double-strand breaks (DSBs) is very common in
cancer cells. The mechanisms and enzymes regulating these events are largely unknown …