Hepatocellular carcinoma (HCC) remains the most predominant type of liver cancer with an
extremely poor prognosis due to its late diagnosis and high recurrence rate. One of the …

The liver is a unique organ for homoeostasis with regenerative capacities. Hepatocytes
possess a remarkable capacity to proliferate upon injury; however, in more severe scenarios …

The CD34 protein was identified almost four decades ago as a biomarker for hematopoietic
stem cell progenitors. CD34 expression of these stem cells has been exploited for …

Over the last decade research on cancer stem cells (CSC) significantly contributed to a
better understanding of tumor biology. Given their similarity to normal stem cells, ie self …

Hepatocellular carcinoma (HCC) is one of the most common cancers with high mortality rate.
It is a heterogeneous cancer with diverse inter-and intra-heterogeneity, also in terms of …

Renal medullary carcinoma (RMC) is a highly aggressive disease associated with sickle
hemoglobinopathies and universal loss of the tumor suppressor gene SMARCB1. RMC has …

CS/ICs have raised great expectations in cancer research and therapy, as eradication of this
key cancer cell type is expected to lead to a complete cure. Unfortunately, the biology of …

The transmembrane phosphoglycoprotein protein CD34 has conventionally been regarded
as a marker for hematopoietic progenitors. Its expression on these cells has been leveraged …

Background Several markers have been reported to be specific for hepatic cancer stem cells
(HCSCs), which is usually thought to be highly associated with poor clinical outcomes …

A large number of cancer stem cells (CSCs) were identified and characterized; however, the
origins and formation of CSCs remain elusive. In this study, we examined the origination of …