mRNA-based vaccines and therapeutics: An in-depth survey of current and upcoming clinical applications
YS Wang, M Kumari, GH Chen, MH Hong… - Journal of Biomedical …, 2023 - Springer
Abstract mRNA-based drugs have tremendous potential as clinical treatments, however, a
major challenge in realizing this drug class will promise to develop methods for safely …
major challenge in realizing this drug class will promise to develop methods for safely …
[HTML][HTML] Nanoformulations targeting immune cells for cancer therapy: mRNA therapeutics
W Yang, J Cao, H Cheng, L Chen, M Yu, Y Chen… - Bioactive Materials, 2023 - Elsevier
The approved worldwide use of two messenger RNA (mRNA) vaccines (BNT162b2 and
mRNA-1273) in late 2020 has proven the remarkable success of mRNA therapeutics …
mRNA-1273) in late 2020 has proven the remarkable success of mRNA therapeutics …
LAG-3 and PD-1 synergize on CD8+ T cells to drive T cell exhaustion and hinder autocrine IFN-γ-dependent anti-tumor immunity
Overcoming immune-mediated resistance to PD-1 blockade remains a major clinical
challenge. Enhanced efficacy has been demonstrated in melanoma patients with combined …
challenge. Enhanced efficacy has been demonstrated in melanoma patients with combined …
STING agonist-derived LNP-mRNA vaccine enhances protective immunity against SARS-CoV-2
Lipid nanoparticle (LNP)-mediated delivery of messenger RNA (mRNA) COVID-19 vaccines
has provided large-scale immune protection to the public. To elicit a robust immune …
has provided large-scale immune protection to the public. To elicit a robust immune …
The miR-29 family facilitates the activation of NK-cell immune responses by targeting the B7-H3 immune checkpoint in neuroblastoma
AS Pathania, H Chava, NK Chaturvedi, S Chava… - Cell Death & …, 2024 - nature.com
Neuroblastoma (NB) is a highly aggressive pediatric cancer that originates from immature
nerve cells, presenting significant treatment challenges due to therapy resistance. Despite …
nerve cells, presenting significant treatment challenges due to therapy resistance. Despite …
IL-27 gene therapy induces Stat3-mediated expansion of CD11b+ Gr1+ myeloid cells and promotes accumulation of M1 macrophages in the tumor microenvironment
IL-27 is a pleiotropic cytokine that exhibits stimulatory/regulatory functions on multiple
lineages of immune cells and has a potential to be used as a therapeutic for cancer. We …
lineages of immune cells and has a potential to be used as a therapeutic for cancer. We …
ASCT2-mediated glutamine uptake of epithelial cells facilitates CCL5-induced T cell infiltration via ROS-STAT3 pathway in oral lichen planus
J Lu, Z Su, W Li, Z Ling, B Cheng, X Yang… - International …, 2023 - Elsevier
Background Oral lichen planus (OLP) is a chronic inflammatory disease characterized by T
cell infiltration at lesion sites. T cell migration is greatly facilitated by chemokines produced …
cell infiltration at lesion sites. T cell migration is greatly facilitated by chemokines produced …
Recent advances in mRNA-based cancer vaccines encoding immunostimulants and their delivery strategies
SM Eslami, X Lu - Journal of Controlled Release, 2024 - Elsevier
The high prevalence of drug resistance, relapse, and unfavorable response rate of
conventional cancer therapies necessitate the development of more efficient treatment …
conventional cancer therapies necessitate the development of more efficient treatment …
[HTML][HTML] The Role of Chemokines in Obesity and Exercise-Induced Weight Loss
W He, H Wang, G Yang, L Zhu, X Liu - Biomolecules, 2024 - mdpi.com
Obesity is a global health crisis that is closely interrelated to many chronic diseases, such as
cardiovascular disease and diabetes. This review provides an in-depth analysis of specific …
cardiovascular disease and diabetes. This review provides an in-depth analysis of specific …