Lipid phosphoinositides are master regulators of multiple cellular functions. Misregulation of
the activity of the lipid kinases that generate phosphoinositides is causative of human …

Solution-phase hydrogen/deuterium exchange (HDX) coupled to mass spectrometry (MS) is
a widespread tool for structural analysis across academia and the biopharmaceutical …

Intracellular Ca 2+ signals are temporally controlled and spatially restricted. Signaling
occurs adjacent to sites of Ca 2+ entry and/or release, where Ca 2+-dependent effectors and …

The polyphosphoinositides (PPIn) are central regulatory lipids that direct membrane function
in eukaryotic cells. Understanding how their synthesis is regulated is crucial to revealing …

The lipid kinase phosphatidylinositol 4 kinase III α (PI4KIIIα/PI4KA) is a master regulator of
the lipid composition and asymmetry of the plasma membrane. PI4KA exists primarily in a …

Lipid phosphoinositides are master signaling molecules in eukaryotic cells and key markers
of organelle identity. Because of these important roles, the kinases and phosphatases that …

Phosphatidylinositol 4-kinase IIIα (PI4KIIIα/PI4KA/OMIM: 600286) is a lipid kinase
generating phosphatidylinositol 4-phosphate (PI4P), a membrane phospholipid with critical …

Calcineurin, the conserved protein phosphatase and target of immunosuppressants, is a
critical mediator of Ca2+ signaling. Here, to discover calcineurin-regulated processes we …

Phosphoinositides are low-abundant lipids that participate in the acquisition of membrane
identity through their spatiotemporal enrichment in specific compartments …

Background: The emergence of chemoresistance in leukemia markedly impedes
chemotherapeutic efficacy and dictates poor prognosis. Recent evidence has revealed that …