The sickle hemoglobin is an abnormal hemoglobin due to point mutation (GAG→ GTG) in
exon 1 of the β globin gene resulting in the substitution of glutamic acid by valine at position …

Nontraumatic osteonecrosis continues to be a challenging problem causing debilitating
major joint diseases. The etiology is multifactorial, but steroid‐and alcohol‐induced …

The aim of this prospective study was to evaluate the long-term efficacy and safety of
hydroxyurea (HU) in patients with sickle cell disease (SCD). Thirty-four patients with sickle …

Chronic opioid therapy (COT) for chronic non-cancer pain is frequently debated, and its
effectiveness is unproven in sickle cell disease (SCD). The authors conducted a descriptive …

Avascular necrosis of femoral head (AVNFH) is a debilitating disease, which affects the
middle aged population. Though the disease is managed using bisphosphonate, it …

Background Many potential causative factors are related to the initiation and progression of
osteonecrosis of the femoral head. The aim of this research was to investigate the etiology …

An injectable hydroxypropyl-β-cyclodextrin (HPβCD) cross-linking of gelatin (Gel) based
hydrogel was embedded with BMSC in vivo bone regeneration of femoral head necrosis …

Purpose To investigate the curative efficacy of osteonecrosis of the femoral head (ONFH) in
a hip-preserving operative approach, by grafting a vascularized greater trochanter flap …

Purpose The purpose of this study was to evaluate clinical and radiological outcomes of
autologous osteochondral transfer (OATS) for femoral head osteonecrosis. Methods Twenty …

Sickle cell disease is an autosomal recessive disorder of the beta-globin gene, with resultant
deformation of the red blood cells and variable clinical outcomes. Nigeria is recognised as …