Kratom (or Ketum) is a psychoactive plant preparation used in Southeast Asia. It is derived
from the plant Mitragyna speciosa Korth. Kratom as well as its main alkaloid, mitragynine …

The use of substances to enhance human abilities is a constant and cross‐cultural feature in
the evolution of humanity. Although much has changed over time, the availability on the …

Zebrafish (Danio rerio) are rapidly emerging as an important model organism for aquatic
neuropharmacology and toxicology research. The behavioral/phenotypic complexity of …

Kratom or its main alkaloid, mitragynine is derived from the plant Mitragyna speciosa Korth
which is indigenous to Southeast Asian countries. This substance has become widely …

Background Opiate addiction is a major health problem in many countries. A crucial
component of the medical treatment is the management of highly aversive opiate withdrawal …

Chronic administration of opioids produces physical dependence and opioid-induced
hyperalgesia. Users claim the Thai traditional tea “kratom” and component alkaloid …

The zebrafish larva stands out as an emergent model organism for translational studies
involving gene or drug screening thanks to its size, genetics, and permeability. At the larval …

Stress is a common cause of neuropsychiatric disorders, evoking multiple behavioral,
endocrine and neuro-immune deficits. Animal models have been extensively used to …

Abstract Introduction Kratom (Mitragyna speciosa) is a tropical plant traditionally used as an
ethnomedicinal remedy for several conditions in South East Asia. Despite the increased …

Kratom (Mitragyna speciosa) is an indigenous plant known for its traditional medicinal use,
and for its addiction potential, in Southeast Asia. In recent years, kratom and its major …