Alternative animal models of aging research

S Holtze, E Gorshkova, S Braude… - Frontiers in Molecular …, 2021 - frontiersin.org
Most research on mechanisms of aging is being conducted in a very limited number of
classical model species, ie, laboratory mouse (Mus musculus), rat (Rattus norvegicus …

Homeostasis and evolution in relation to regeneration and repair

A Cano‐Martínez, ME Rubio‐Ruiz… - The Journal of …, 2024 - Wiley Online Library
Homeostasis constitutes a key concept in physiology and refers to self‐regulating processes
that maintain internal stability when adjusting to changing external conditions. It diminishes …

Spatial transcriptomics reveals metabolic changes underly age-dependent declines in digit regeneration

RJ Tower, E Busse, J Jaramillo, M Lacey, K Hoffseth… - Elife, 2022 - elifesciences.org
De novo limb regeneration after amputation is restricted in mammals to the distal digit tip.
Central to this regenerative process is the blastema, a heterogeneous population of lineage …

Construction of the axolotl cell landscape using combinatorial hybridization sequencing at single-cell resolution

F Ye, G Zhang, WE, H Chen, C Yu, L Yang… - Nature …, 2022 - nature.com
Abstract The Mexican axolotl (Ambystoma mexicanum) is a well-established tetrapod model
for regeneration and developmental studies. Remarkably, neotenic axolotls may undergo …

Regenerating soft robots through neural cellular automata

K Horibe, K Walker, S Risi - … European Conference, EuroGP 2021, Held as …, 2021 - Springer
Morphological regeneration is an important feature that highlights the environmental
adaptive capacity of biological systems. Lack of this regenerative capacity significantly limits …

Mexican axolotl optimization: A novel bioinspired heuristic

Y Villuendas-Rey, JL Velázquez-Rodríguez… - Mathematics, 2021 - mdpi.com
When facing certain problems in science, engineering or technology, it is not enough to find
a solution, but it is essential to seek and find the best possible solution through optimization …

Positional memory in vertebrate regeneration: a century's insights from the salamander limb

L Otsuki, EM Tanaka - Cold Spring Harbor Perspectives …, 2022 - cshperspectives.cshlp.org
Salamanders, such as axolotls and newts, can regenerate complex tissues including entire
limbs. But what mechanisms ensure that an amputated limb regenerates a limb, and not a …

Unravelling the limb regeneration mechanisms of Polypedates maculatus, a sub-tropical frog, by transcriptomics

C Mahapatra, P Naik, SK Swain, PP Mohapatra - BMC genomics, 2023 - Springer
Background Regeneration studies help to understand the strategies that replace a lost or
damaged organ and provide insights into approaches followed in regenerative medicine …

Postembryonic development and aging of the appendicular skeleton in Ambystoma mexicanum

C Riquelme‐Guzmán, M Schuez, A Böhm… - Developmental …, 2022 - Wiley Online Library
Background The axolotl is a key model to study appendicular regeneration. The limb
complexity resembles that of humans in structure and tissue components; however, axolotl …

Recent advances in neurotechnology-based biohybrid robots

G Chen, D Dang, C Zhang, L Qin, T Yan, W Wang… - Soft Matter, 2024 - pubs.rsc.org
Biohybrid robots retain the innate biological characteristics and behavioral traits of animals,
making them valuable in applications such as disaster relief, exploration of unknown …