Colorectal cancer (CRC) is the fourth leading cause of cancer death worldwide, and
constitutive activation of the Wnt signaling pathway is universal in most CRC cases. Wnt …

The nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3)
inflammasome is an important part of the natural immune system that plays an important role …

Immune checkpoint blockade (ICB) therapies have significantly prolonged patient survival
across multiple tumor types, particularly in melanoma. Interestingly, sex-specific differences …

Endometriosis is a known estrogen-dependent inflammatory disease affecting reproductive-
aged women. Common symptoms include pelvic pain, dysmenorrhea, dyspareunia, heavy …

OBJECTIVE Subarachnoid hemorrhage (SAH) due to intracranial aneurysm (IA) rupture is
often a devastating event. Since the incidence of SAH increases especially in menopause, it …

In response to a variety of stresses, mammalian cells activate the inflammasome for targeted
caspase-dependent pyroptosis. The research community has recently begun to deduce that …

Recent studies have reported the anticancer activity of huaier extract in various human
malignancies. However, little is known about the effect of huaier extract in non‐small cell …

Although ovarian sex steroids could have protective roles against colorectal cancer (CRC) in
women, little is currently known about their potential anti-tumorigenic effects in men. Hence …

As the essential sexual hormone, estrogen and its receptor has been proved to participate in
the regulation of autoimmunity diseases and anti-tumor immunity. The adjustment of tumor …

The overall survival of metastatic colon adenocarcinoma (COAD) remains poor, so it is
important to explore the mechanisms of metastasis and invasion. This study aimed to identify …