Diabetes is pervasive, exponentially growing in prevalence, and outpacing most diseases
globally. In this Series paper, we use new theoretical frameworks and a narrative review of …

Today, whole-exome sequencing (WES) is used to conduct the massive screening of
structural and regulatory genes in order to identify the allele frequencies of disease …

Over the last several decades, there has been a considerable growth in type 2 diabetes
(T2DM) in Asians. A pathophysiological mechanism in Asian T2DM is closely linked to low …

Abstract Type 2 diabetes (T2D) is a heterogeneous disease that develops through diverse
pathophysiological processes. To characterise the genetic contribution to these processes …

Recent studies have suggested an association between obesity and dyslipidemia in the
development of type 2 diabetes (T2D). The purpose of this study was to explore the causal …

A polygenic risk score (PRS) is derived from a genome-wide association study and
represents an aggregate of thousands of single-nucleotide polymorphisms that provide a …

Recent studies have suggested an association between iritis or uveitis and glaucoma. This
study investigated the causal relationship between glaucoma and iritis and uveitis as …

据报道, 全球20~ 79 岁的糖尿病患者约5.37 亿, 约有670 万成年人死于糖尿病或糖尿病并发症.
而我国已成为世界上糖尿病患者人数最多的国家. 2 型糖尿病(type 2 diabetes mellitus, T2DM) …

Since early 2007, the establishment of international consortia and biobanks has catalyzed
the performance of large-scale genomic studies. These efforts have driven an explosion in …

Background: Genome-wide polygenic risk scores (PRS) have shown high specificity and
sensitivity in predicting type 2 diabetes (T2D) risk in Europeans. However, the PRS-driven …