The multifunctional or moonlighting protein CD26/DPPIV

E Boonacker, CJF Van Noorden - European journal of cell biology, 2003 - Elsevier
CD26/DPPIV can be considered a moonlighting protein because it is a multifunctional
protein that exerts its different functions depending on cell type and intra-or extracellular …

Proline specific peptidases

DF Cunningham, B O'Connor - … et Biophysica Acta (BBA)-Protein Structure …, 1997 - Elsevier
Proline is unique among the 20 amino acids due to its cyclic structure. This specific
conformation imposes many restrictions on the structural aspects of peptides and proteins …

The crystal structure of dipeptidyl peptidase IV (CD26) reveals its functional regulation and enzymatic mechanism

M Engel, T Hoffmann, L Wagner… - Proceedings of the …, 2003 - National Acad Sciences
The membrane-bound glycoprotein dipeptidyl peptidase IV (DP IV, CD26) is a unique
multifunctional protein, acting as receptor, binding and proteolytic molecule. We have …

Molecular characterization of dipeptidyl peptidase activity in serum: soluble CD26/dipeptidyl peptidase IV is responsible for the release of X‐Pro dipeptides

C Durinx, AM Lambeir, E Bosmans… - European Journal of …, 2000 - Wiley Online Library
Dipeptidyl peptidase IV (DPPIV, EC 3.4. 14.5) is a serine type protease with an important
modulatory activity on a number of chemokines, neuropeptides and peptide hormones. It is …

On the origin of serum CD26 and its altered concentration in cancer patients

OJ Cordero, FJ Salgado, M Nogueira - Cancer immunology …, 2009 - Springer
Abstract Dipeptidyl peptidase IV (DPP-IV), assigned to the CD26 cluster, is expressed on
epithelial cells and lymphocytes and is a multifunctional or pleiotropic protein. Its peptidase …

Regulation of the receptor specificity and function of the chemokine RANTES (regulated on activation, normal T cell expressed and secreted) by dipeptidyl peptidase …

T Oravecz, M Pall, G Roderiquez, MD Gorrell… - The Journal of …, 1997 - rupress.org
CD26 is a leukocyte activation marker that possesses dipeptidyl peptidase IV activity but
whose natural substrates and immunological functions have not been clearly defined …

The intricate interface between immune system and metabolism

G Matarese, A La Cava - Trends in immunology, 2004 - cell.com
Increasing experimental evidence indicates that several factors that influence metabolism
also play a role in the regulation of immune responses. Dissection of the interface …

Inhibition of CD26/dipeptidyl peptidase IV activity in vivo prolongs cardiac allograft survival in rat recipients1, 2

S Korom, I De Meester, THW Stadlbauer… - …, 1997 - journals.lww.com
The CD26 antigen, one of the major costimulatory molecules in T cell activation, was shown
to possess dipeptidyl peptidase IV (DPP IV) activity. Previously, we demonstrated that …

Unravelling the immunological roles of dipeptidyl peptidase 4 (DPP4) activity and/or structure homologue (DASH) proteins

L Wagner, C Klemann, M Stephan… - Clinical & …, 2016 - academic.oup.com
Summary Dipeptidyl peptidase (DPP) 4 (CD26, DPP4) is a multi-functional protein involved
in T cell activation by co-stimulation via its association with adenosine deaminase (ADA) …

Anti-HIV-1 and chemotactic activities of human stromal cell-derived factor 1α (SDF-1α) and SDF-1β are abolished by CD26/dipeptidyl peptidase IV-mediated cleavage

T Shioda, H Kato, Y Ohnishi… - Proceedings of the …, 1998 - National Acad Sciences
CD26 is a leukocyte-activation antigen that is expressed on T lymphocytes and
macrophages and possesses dipeptidyl peptidase IV (DPPIV) activity, whose natural …