Assessment of enzyme inhibition: a review with examples from the development of monoamine oxidase and cholinesterase inhibitory drugs
RR Ramsay, KF Tipton - Molecules, 2017 - mdpi.com
The actions of many drugs involve enzyme inhibition. This is exemplified by the inhibitors of
monoamine oxidases (MAO) and the cholinsterases (ChE) that have been used for several …
monoamine oxidases (MAO) and the cholinsterases (ChE) that have been used for several …
Recent development of multifunctional agents as potential drug candidates for the treatment of Alzheimer's disease
N Guzior, A Wieckowska, D Panek… - Current medicinal …, 2015 - ingentaconnect.com
Alzheimer's disease (AD) is a complex and progressive neurodegenerative disorder. The
available therapy is limited to the symptomatic treatment and its efficacy remains …
available therapy is limited to the symptomatic treatment and its efficacy remains …
Rivastigmine: the advantages of dual inhibition of acetylcholinesterase and butyrylcholinesterase and its role in subcortical vascular dementia and Parkinson's …
Several studies have demonstrated clinical benefits of sustained cholinesterase inhibition
with rivastigmine in Alzheimer's disease (AD) and Parkinson's disease dementia (PDD) …
with rivastigmine in Alzheimer's disease (AD) and Parkinson's disease dementia (PDD) …
Multitarget compounds bearing tacrine-and donepezil-like structural and functional motifs for the potential treatment of Alzheimer's disease
L Ismaili, B Refouvelet, M Benchekroun, S Brogi… - Progress in …, 2017 - Elsevier
Alzheimer's disease is a multifactorial and fatal neurodegenerative disorder characterized
by decline of cholinergic function, deregulation of other neurotransmitter systems, β-amyloid …
by decline of cholinergic function, deregulation of other neurotransmitter systems, β-amyloid …
Fluorescent determination of butyrylcholinesterase activity and its application in biological imaging and pesticide residue detection
Q Zhang, C Fu, X Guo, J Gao, P Zhang, C Ding - ACS sensors, 2021 - ACS Publications
Butyrylcholinesterase (BChE) is an essential human cholinesterase relevant to liver
conditions and neurodegenerative diseases, which makes it a pivotal biomarker of health. It …
conditions and neurodegenerative diseases, which makes it a pivotal biomarker of health. It …
Structure and therapeutic uses of butyrylcholinesterase: application in detoxification, Alzheimer's disease, and fat metabolism
S Xing, Q Li, B Xiong, Y Chen, F Feng… - Medicinal Research …, 2021 - Wiley Online Library
Structural information of butyrylcholinesterase (BChE) and its variants associated with
several diseases are discussed here. Pure human BChE has been proved safe and effective …
several diseases are discussed here. Pure human BChE has been proved safe and effective …
Ratiometric imaging of butyrylcholinesterase activity in mice with nonalcoholic fatty liver using an AIE-based fluorescent probe
C Xiang, J Xiang, X Yang, C Li, L Zhou… - Journal of Materials …, 2022 - pubs.rsc.org
Butyrylcholinesterase (BChE) is an essential human biomarker which is related to liver and
neurodegenerative diseases. It is of great significance to develop a fluorescent probe that …
neurodegenerative diseases. It is of great significance to develop a fluorescent probe that …
Discovery of Butyrylcholinesterase-Activated Near-Infrared Fluorogenic Probe for Live-Cell and In Vivo Imaging
Butyrylcholinesterase (BChE) is widely distributed in various tissues and highly implicated in
several important human diseases, especially Alzheimer's disease (AD). However, the role …
several important human diseases, especially Alzheimer's disease (AD). However, the role …
Synthesis and biological evaluation of new cholinesterase inhibitors for Alzheimer's disease
Alzheimer's disease (AD) is a neurodegenerative disorder mostly influencing the elderly,
and causes death due to dementia. The main pathogenic feature connected with the …
and causes death due to dementia. The main pathogenic feature connected with the …
Why has butyrylcholinesterase been retained? Structural and functional diversification in a duplicated gene
G Johnson, SW Moore - Neurochemistry international, 2012 - Elsevier
While acetylcholinesterase (EC 3.1. 1.7) has a clearly defined role in neurotransmission, the
functions of its sister enzyme butyrylcholinesterase (EC 3.1. 1.8) are more obscure …
functions of its sister enzyme butyrylcholinesterase (EC 3.1. 1.8) are more obscure …