Worse progression of COVID‐19 in men: is testosterone a key factor?

VA Giagulli, E Guastamacchia, T Magrone, E Jirillo… - …, 2021 - Wiley Online Library
Background The novel severe acute respiratory syndrome coronavirus (SARS‐CoV‐2)
disease 2019 (COVID‐19) seems to have a worse clinical course among infected men …

The transmembrane protease TMPRSS2 as a therapeutic target for COVID-19 treatment

L Wettstein, F Kirchhoff, J Münch - International Journal of Molecular …, 2022 - mdpi.com
TMPRSS2 is a type II transmembrane protease with broad expression in epithelial cells of
the respiratory and gastrointestinal tract, the prostate, and other organs. Although the …

[HTML][HTML] Hyperglycemia in acute COVID-19 is characterized by insulin resistance and adipose tissue infectivity by SARS-CoV-2

M Reiterer, M Rajan, N Gómez-Banoy, JD Lau… - Cell metabolism, 2021 - cell.com
Individuals infected with SARS-CoV-2 who also display hyperglycemia suffer from longer
hospital stays, higher risk of developing acute respiratory distress syndrome (ARDS), and …

Withanone and Withaferin-A are predicted to interact with transmembrane protease serine 2 (TMPRSS2) and block entry of SARS-CoV-2 into cells

V Kumar, JK Dhanjal, P Bhargava, A Kaul… - Journal of …, 2022 - Taylor & Francis
Abstract Coronavirus disease 2019 (COVID-19) initiated in December 2019 in Wuhan,
China and became pandemic causing high fatality and disrupted normal life calling world …

Alpha-1 antitrypsin inhibits TMPRSS2 protease activity and SARS-CoV-2 infection

L Wettstein, T Weil, C Conzelmann, JA Müller… - Nature …, 2021 - nature.com
SARS-CoV-2 is a respiratory pathogen and primarily infects the airway epithelium. As our
knowledge about innate immune factors of the respiratory tract against SARS-CoV-2 is …

An enzymatic TMPRSS2 assay for assessment of clinical candidates and discovery of inhibitors as potential treatment of COVID-19

JH Shrimp, SC Kales, PE Sanderson… - ACS pharmacology & …, 2020 - ACS Publications
SARS-CoV-2 is the viral pathogen causing the COVID19 global pandemic. Consequently,
much research has gone into the development of preclinical assays for the discovery of new …

The oncogene ERG: a key factor in prostate cancer

P Adamo, MR Ladomery - Oncogene, 2016 - nature.com
ETS-related gene (ERG) is a member of the E-26 transformation-specific (ETS) family of
transcription factors with roles in development that include vasculogenesis, angiogenesis …

Structure, function and pathophysiology of protease activated receptors

MN Adams, R Ramachandran, MK Yau, JY Suen… - Pharmacology & …, 2011 - Elsevier
Discovered in the 1990s, protease activated receptors 1 (PARs) are membrane-spanning
cell surface proteins that belong to the G protein coupled receptor (GPCR) family. A defining …

Priming of SARS-CoV-2 S protein by several membrane-bound serine proteinases could explain enhanced viral infectivity and systemic COVID-19 infection

P Fuentes-Prior - Journal of Biological Chemistry, 2021 - ASBMB
The ongoing COVID-19 pandemic has already caused over a million deaths worldwide, and
this death toll will be much higher before effective treatments and vaccines are available …

Proteolytic activation of influenza viruses by serine proteases TMPRSS2 and HAT from human airway epithelium

E Böttcher, T Matrosovich, M Beyerle… - Journal of …, 2006 - Am Soc Microbiol
Host cell proteases that cleave the hemagglutinin (HA) of influenza viruses in the human
respiratory tract are still not identified. Here we cloned two human type II transmembrane …