How do minds emerge from developing brains? According to “neural constructivism,” the
representational features of cortex are built from the dynamic interaction between neural …

Evidence implicating the β-amyloid protein (Aβ) in the pathogenesis of Alzheimer's disease
has steadily accumulated. However, the mechanism by which Aβ causes dementia is …

The structural dynamics of synapses probably has a crucial role in the development and
plasticity of the nervous system. In the mammalian brain, the vast majority of excitatory axo …

Synapse formation and elimination occur throughout life, but the magnitude of such changes
at distinct developmental stages remains unclear. Using transgenic mice overexpressing …

Although maturing neurons undergo a precipitous decline in the expression of genes
associated with developmental axon growth, structural changes in axon arbors occur in the …

One of the major limitations in the current set of techniques available to neuroscientists is a
dearth of methods for imaging individual cells deep within the brains of live animals. To …

The glutamatergic neuromuscular synapse in Drosophila forms and differentiates into
distinct boutons in the embryo and grows by sprouting new boutons throughout larval life …

The major goal of developmental neurobiology is to understand how the nervous system is
put together. A central theme that has emerged from research in this field over the last …

A major role of DNA-methyltransferase (MTase) is thought to be maintaining the DNA methyl-
ation profile through DNA replication. However, previous surveys of mRNA distribution in …

The glutamatergic neuromuscular junction (NMJ) in Drosophila adds new boutons and
branches during larval development. We generated transgenic fruit flies that express a novel …