Accumulating evidence suggests that the molecular circadian clock is crucial in blood
pressure (BP) control. Circadian rhythms are controlled by the central clock, which resides in …

An intrinsic cellular circadian clock is located in nearly every cell of the body. The peripheral
circadian clocks within the cells of the kidney contribute to the regulation of a variety of renal …

Healthy individuals exhibit blood pressure variation over a 24-hour period with higher blood
pressure during wakefulness and lower blood pressure during sleep. Loss or disruption of …

Sex as a biological variable is the focus of much literature and has been emphasized by the
National Institutes of Health, in part, to remedy a long history of male-dominated studies in …

Hypertension is the primary cause of cardiovascular diseases (CVD) and is responsible for
nearly 9 million deaths worldwide annually. Increasing evidence indicates that in addition to …

Kidney function is regulated by the circadian clock. Not only do glomerular filtration rate and
urinary excretion oscillate during the day, but the expressions of several renal transporter …

The scientific literature is littered with the adjective significant and the descriptive phrase
statistically significant. Established members of the statistical community now recommend …

Recent studies suggest that deletion of the core clock gene Bmal1 in the kidney has a
significant influence on renal physiological functions. However, the role of renal Bmal1 in …

Timing of food intake has become a critical factor in determining overall cardiometabolic
health. We hypothesized that timing of food intake entrains circadian rhythms of blood …

Blood pressure (BP) follows a circadian rhythm, it increases on waking in the morning and
decreases during sleeping at night. Disruption of the circadian BP rhythm has been reported …