Sex and gender: modifiers of health, disease, and medicine
Clinicians can encounter sex and gender disparities in diagnostic and therapeutic
responses. These disparities are noted in epidemiology, pathophysiology, clinical …
responses. These disparities are noted in epidemiology, pathophysiology, clinical …
[HTML][HTML] Sex and gender differences and biases in artificial intelligence for biomedicine and healthcare
Precision Medicine implies a deep understanding of inter-individual differences in health
and disease that are due to genetic and environmental factors. To acquire such …
and disease that are due to genetic and environmental factors. To acquire such …
An analysis of neuroscience and psychiatry papers published from 2009 and 2019 outlines opportunities for increasing discovery of sex differences
Sex differences exist in many neurological and psychiatric diseases, but these have not
always been addressed adequately in research. In order to address this, it is necessary to …
always been addressed adequately in research. In order to address this, it is necessary to …
Sex differences in pharmacokinetics predict adverse drug reactions in women
I Zucker, BJ Prendergast - Biology of sex differences, 2020 - Springer
Background Women experience adverse drug reactions, ADRs, nearly twice as often as
men, yet the role of sex as a biological factor in the generation of ADRs is poorly understood …
men, yet the role of sex as a biological factor in the generation of ADRs is poorly understood …
Digitizing clinical trials
OT Inan, P Tenaerts, SA Prindiville, HR Reynolds… - NPJ digital …, 2020 - nature.com
Clinical trials are a fundamental tool used to evaluate the efficacy and safety of new drugs
and medical devices and other health system interventions. The traditional clinical trials …
and medical devices and other health system interventions. The traditional clinical trials …
Sex as a biological variable: a 5-year progress report and call to action
ME Arnegard, LA Whitten, C Hunter… - Journal of Women's …, 2020 - liebertpub.com
A little over 5 years ago, the US National Institutes of Health (NIH) announced the intention
to develop policies to require applicants to report plans to balance male and female cells …
to develop policies to require applicants to report plans to balance male and female cells …
[HTML][HTML] Clinical trial landscape in NASH
SA Harrison, R Loomba, J Dubourg, V Ratziu… - Clinical …, 2023 - Elsevier
Nonalcoholic fatty liver disease consists of a spectrum starting from nonalcoholic fatty liver
disease that may progress to nonalcoholic steatohepatitis (NASH), which can lead to …
disease that may progress to nonalcoholic steatohepatitis (NASH), which can lead to …
A 10-year follow-up study of sex inclusion in the biological sciences
In 2016, to address the historical overrepresentation of male subjects in biomedical
research, the US National Institutes of Health implemented a policy requiring investigators to …
research, the US National Institutes of Health implemented a policy requiring investigators to …
Why and how to account for sex and gender in brain and behavioral research
Long overlooked in neuroscience research, sex and gender are increasingly included as
key variables potentially impacting all levels of neurobehavioral analysis. Still, many …
key variables potentially impacting all levels of neurobehavioral analysis. Still, many …
Sex-and gender-based pharmacological response to drugs
In humans, the combination of all sex-specific genetic, epigenetic, and hormonal influences
of biologic sex produces different in vivo environments for male and female cells. We dissect …
of biologic sex produces different in vivo environments for male and female cells. We dissect …