Recent advances in understanding the protein corona of nanoparticles and in the formulation of “stealthy” nanomaterials

R Rampado, S Crotti, P Caliceti, S Pucciarelli… - … in bioengineering and …, 2020 - frontiersin.org
In the last decades, the staggering progress in nanotechnology brought around a wide and
heterogeneous range of nanoparticle-based platforms for the diagnosis and treatment of …

The protein corona and its effects on nanoparticle-based drug delivery systems

H Li, Y Wang, Q Tang, D Yin, C Tang, E He, L Zou… - Acta biomaterialia, 2021 - Elsevier
In most cases, once nanoparticles (NPs) enter the blood, their surface is covered by
biological molecules, especially proteins, forming a so-called protein corona (PC). As a …

In vivo formation of protein corona on gold nanoparticles. The effect of their size and shape

R García-Álvarez, M Hadjidemetriou… - Nanoscale, 2018 - pubs.rsc.org
The efficacy of drug delivery and other nanomedicine-related therapies largely relies on the
ability of nanoparticles to reach the target organ. However, when nanoparticles are injected …

Hard and soft protein corona of nanomaterials: Analysis and relevance

R García-Álvarez, M Vallet-Regí - Nanomaterials, 2021 - mdpi.com
Upon contact with a biological milieu, nanomaterials tend to interact with biomolecules
present in the media, especially proteins, leading to the formation of the so-called “protein …

Opsonins and dysopsonins of nanoparticles: facts, concepts, and methodological guidelines

E Papini, R Tavano, F Mancin - Frontiers in immunology, 2020 - frontiersin.org
Understanding the effects mediated by a set of nanoparticle (NP)-bound host biomolecules,
often indicated with the umbrella term of NP corona, is essential in nanomedicine …

The impact of protein corona on the biological behavior of targeting nanomedicines

M Farshbaf, H Valizadeh, Y Panahi, Y Fatahi… - International Journal of …, 2022 - Elsevier
For successful translation of targeting nanomedicines from bench to bedside, it is vital to
address their most common drawbacks namely rapid clearance and off-target accumulation …

Protein corona, influence on drug delivery system and its improvement strategy: A review

F Guo, S Luo, L Wang, M Wang, F Wu, Y Wang… - International Journal of …, 2024 - Elsevier
Nano drug delivery systems offer several benefits, including enhancing drug solubility,
regulating drug release, prolonging drug circulation time, and minimized toxicity and side …

The interaction between nanoparticles-protein corona complex and cells and its toxic effect on cells

N Liu, M Tang, J Ding - Chemosphere, 2020 - Elsevier
Once nanoparticles (NPs) contact with the biological fluids, the proteins immediately adsorb
onto their surface, forming a layer called protein corona (PC), which bestows the biological …

Considerations for extracellular vesicle and lipoprotein interactions in cell culture assays

S Busatto, Y Yang, D Iannotta… - Journal of …, 2022 - Wiley Online Library
With an exponential increase in extracellular vesicle (EV) studies in the past decade, focus
has been placed on standardization of experimental design to ensure inter‐study …

Artificial engineering of the protein corona at bio-nano interfaces for improved cancer-targeted nanotherapy

S Khan, M Sharifi, JP Gleghorn, MMN Babadaei… - Journal of Controlled …, 2022 - Elsevier
Nanoparticles (NPs) have been used in numerous applications as anticancer, antibacterial
and antioxidant agents. Artificial engineering of protein interactions with NPs in biological …