Chromatin accessibility profiling by ATAC-seq
The assay for transposase-accessible chromatin using sequencing (ATAC-seq) provides a
simple and scalable way to detect the unique chromatin landscape associated with a cell …
simple and scalable way to detect the unique chromatin landscape associated with a cell …
Advancing cancer research and medicine with single-cell genomics
Single-cell sequencing (SCS) has impacted many areas of cancer research and improved
our understanding of intratumor heterogeneity, the tumor microenvironment, metastasis, and …
our understanding of intratumor heterogeneity, the tumor microenvironment, metastasis, and …
[HTML][HTML] Mechanical regulation of transcription: recent advances
Mechanotransduction is the ability of a cell to sense mechanical cues from its
microenvironment and convert them into biochemical signals to elicit adaptive transcriptional …
microenvironment and convert them into biochemical signals to elicit adaptive transcriptional …
Therapeutic ligands antagonize estrogen receptor function by impairing its mobility
Summary Estrogen receptor-positive (ER+) breast cancers frequently remain dependent on
ER signaling even after acquiring resistance to endocrine agents, prompting the …
ER signaling even after acquiring resistance to endocrine agents, prompting the …
Innate immune training restores pro-reparative myeloid functions to promote remyelination in the aged central nervous system
The reduced ability of the central nervous system to regenerate with increasing age limits
functional recovery following demyelinating injury. Previous work has shown that myelin …
functional recovery following demyelinating injury. Previous work has shown that myelin …
Dynamic transcriptome and chromatin architecture in granulosa cells during chicken folliculogenesis
Folliculogenesis is a complex biological process involving a central oocyte and its
surrounding somatic cells. Three-dimensional chromatin architecture is an important …
surrounding somatic cells. Three-dimensional chromatin architecture is an important …
Quantification, dynamic visualization, and validation of bias in ATAC-seq data with ataqv
The assay for transposase-accessible chromatin using sequencing (ATAC-seq) has become
the preferred method for mapping chromatin accessibility due to its time and input material …
the preferred method for mapping chromatin accessibility due to its time and input material …
Nuclear pore protein NUP210 depletion suppresses metastasis through heterochromatin-mediated disruption of tumor cell mechanical response
Mechanical signals from the extracellular microenvironment have been implicated in tumor
and metastatic progression. Here, we identify nucleoporin NUP210 as a metastasis …
and metastatic progression. Here, we identify nucleoporin NUP210 as a metastasis …
Genome-wide estrogen receptor activity in breast cancer
AM Farcas, S Nagarajan, S Cosulich, JS Carroll - Endocrinology, 2021 - academic.oup.com
The largest subtype of breast cancer is characterized by the expression and activity of the
estrogen receptor alpha (ERalpha/ER). Although several effective therapies have …
estrogen receptor alpha (ERalpha/ER). Although several effective therapies have …
HIV vaccine candidate efficacy in female macaques mediated by cAMP-dependent efferocytosis and V2-specific ADCC
The development of an effective vaccine to protect against HIV acquisition will be greatly
bolstered by in-depth understanding of the innate and adaptive responses to vaccination …
bolstered by in-depth understanding of the innate and adaptive responses to vaccination …