Sources, resolution and physiological relevance of R-loops and RNA–DNA hybrids
RNA–DNA hybrids are generated during transcription, DNA replication and DNA repair and
are crucial intermediates in these processes. When RNA–DNA hybrids are stably formed in …
are crucial intermediates in these processes. When RNA–DNA hybrids are stably formed in …
Walking a tightrope: the complex balancing act of R-loops in genome stability
JR Brickner, JL Garzon, KA Cimprich - Molecular cell, 2022 - cell.com
Although transcription is an essential cellular process, it is paradoxically also a well-
recognized cause of genomic instability. R-loops, non-B DNA structures formed when …
recognized cause of genomic instability. R-loops, non-B DNA structures formed when …
Regulatory R-loops as facilitators of gene expression and genome stability
C Niehrs, B Luke - Nature reviews Molecular cell biology, 2020 - nature.com
R-loops are three-stranded structures that harbour an RNA–DNA hybrid and frequently form
during transcription. R-loop misregulation is associated with DNA damage, transcription …
during transcription. R-loop misregulation is associated with DNA damage, transcription …
S1P-dependent interorgan trafficking of group 2 innate lymphoid cells supports host defense
Innate lymphoid cells (ILCs) are innate counterparts of adaptive T lymphocytes, contributing
to host defense, tissue repair, metabolic homeostasis, and inflammatory diseases. ILCs have …
to host defense, tissue repair, metabolic homeostasis, and inflammatory diseases. ILCs have …
Activation of homologous recombination in G1 preserves centromeric integrity
Centromeric integrity is key for proper chromosome segregation during cell division.
Centromeres have unique chromatin features that are essential for centromere …
Centromeres have unique chromatin features that are essential for centromere …
Mechanisms of oncogene-induced replication stress: jigsaw falling into place
P Kotsantis, E Petermann, SJ Boulton - Cancer discovery, 2018 - AACR
Oncogene activation disturbs cellular processes and accommodates a complex landscape
of changes in the genome that contribute to genomic instability, which accelerates mutation …
of changes in the genome that contribute to genomic instability, which accelerates mutation …
R loops: new modulators of genome dynamics and function
JM Santos-Pereira, A Aguilera - Nature Reviews Genetics, 2015 - nature.com
R loops are nucleic acid structures composed of an RNA–DNA hybrid and a displaced
single-stranded DNA. Recently, evidence has emerged that R loops occur more often in the …
single-stranded DNA. Recently, evidence has emerged that R loops occur more often in the …
Prevalent, dynamic, and conserved R-loop structures associate with specific epigenomic signatures in mammals
R-loops are three-stranded nucleic acid structures formed upon annealing of an RNA strand
to one strand of duplex DNA. We profiled R-loops using a high-resolution, strand-specific …
to one strand of duplex DNA. We profiled R-loops using a high-resolution, strand-specific …
Senataxin resolves RNA: DNA hybrids forming at DNA double-strand breaks to prevent translocations
Ataxia with oculomotor apraxia 2 (AOA-2) and amyotrophic lateral sclerosis (ALS4) are
neurological disorders caused by mutations in the gene encoding for senataxin (SETX), a …
neurological disorders caused by mutations in the gene encoding for senataxin (SETX), a …
Deep inside the epigenetic memories of stressed plants
Recent evidence sheds light on the peculiar type of plant intelligence. Plants have
developed complex molecular networks that allow them to remember, choose, and make …
developed complex molecular networks that allow them to remember, choose, and make …