Stem cell factor (SCF) is a dimeric molecule that exerts its biological functions by binding to
and activating the receptor tyrosine kinase c-Kit. Activation of c-Kit leads to its …

c-Kit, a receptor tyrosine kinase, is involved in intracellular signaling, and the mutated form
of c-Kit plays a crucial role in occurrence of some cancers. The function of c-Kit has led to the …

Melanoma, originating from epidermal melanocytes, is a heterogeneous disease that has
the highest mortality rate among all types of skin cancers. Numerous studies have revealed …

Abstract c-kit is a classical proto-oncogene that encodes a receptor tyrosine kinase (RTK)
that responds to stem cell factor (SCF). C-KIT signaling is a critical regulator of cell …

Together with its ligand, stem cell factor, the receptor tyrosine kinase c-Kit is a key controlling
receptor for a number of cell types, including hematopoietic stem cells, mast cells …

Most gastrointestinal stromal tumors (GISTs) express constitutively activated forms of the KIT
receptor tyrosine kinase protein, resulting from oncogenic mutations in the extracellular …

Kit is a receptor tyrosine kinase (RTK) that binds stem cell factor. This receptor ligand
combination is important for normal hematopoiesis, as well as pigmentation, gut function …

Stem cell factor (SCF), the ligand of the c-Kit receptor, is expressed by various structural and
inflammatory cells in the airways. Binding of SCF to c-Kit leads to activation of multiple …

Signaling by stem cell factor and Kit, its receptor, plays important roles in gametogenesis,
hematopoiesis, mast cell development and function, and melanogenesis. Moreover, human …

Metastasis is the primary cause of cancer patient morbidity and mortality, but due to
persisting gaps in our knowledge, it remains untreatable. Metastases often occur as patient …