Age-related mitochondrial dysfunction as a key factor in COVID-19 disease

DJM Fernández-Ayala, P Navas… - Experimental gerontology, 2020 - Elsevier
SARS-CoV-2 causes a severe pneumonia (COVID-19) that affects essentially elderly
people. In COVID-19, macrophage infiltration into the lung causes a rapid and intense …

Mitochondrial dynamics and mitophagy in lung disorders

A Sharma, S Ahmad, T Ahmad, S Ali, MA Syed - Life sciences, 2021 - Elsevier
Mitochondria are biosynthetic, bioenergetic, and signaling organelles which are critical for
physiological adaptations and cellular stress responses to the environment. Various …

[HTML][HTML] The Janus kinase 1/2 inhibitor ruxolitinib in COVID-19 with severe systemic hyperinflammation

F La Rosée, HC Bremer, I Gehrke, A Kehr, A Hochhaus… - Leukemia, 2020 - nature.com
A subgroup of patients with severe COVID-19 suffers from progression to acute respiratory
distress syndrome and multiorgan failure. These patients present with progressive …

[HTML][HTML] COVID-19 induces neuroinflammation and loss of hippocampal neurogenesis

R Klein, A Soung, C Sissoko, A Nordvig, P Canoll… - Research …, 2021 - ncbi.nlm.nih.gov
Abstract Infection with the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-
2) is associated with onset of neurological and psychiatric symptoms during and after the …

[HTML][HTML] A public health perspective of aging: do hyper-inflammatory syndromes such as COVID-19, SARS, ARDS, cytokine storm syndrome, and post-ICU syndrome …

A Bektas, SH Schurman, C Franceschi, L Ferrucci - Immunity & Ageing, 2020 - Springer
A central clinical question as the world deals with the COVID-19 pandemic is what the long-
term sequelae for the millions of individuals will be who recover from the hyperinflammatory …

[HTML][HTML] The potential of glycyrrhizin and licorice extract in combating COVID-19 and associated conditions

AA Gomaa, YA Abdel-Wadood - Phytomedicine plus, 2021 - Elsevier
Background Several recent studies have stated that glycyrrhizin and licorice extract are
present in most traditional Chinese medicine formulas used against SARS-CoV-2 in China …

Tratamiento farmacológico de la COVID-19: revisión narrativa de los Grupos de Trabajo de Enfermedades Infecciosas y Sepsis (GTEIS) y del Grupo de Trabajo de …

E Díaz, RA Menéndez, PV Cortés, MG Escapa… - Medicina intensiva, 2021 - Elsevier
La infección por el virus SARS-CoV-2, denominada COVID-19 (COronaVIrus Disease 19),
fue detectada inicialmente en China en diciembre 2019, y posteriormente se ha diseminado …

Do nutrients and other bioactive molecules from foods have anything to say in the treatment against COVID-19?

JL Quiles, L Rivas-García, A Varela-López… - Environmental …, 2020 - Elsevier
The repositioning of therapeutic agents already approved by the regulatory agencies for the
use of drugs is very interesting due to the immediacy of their use; similarly, the possibility of …

SARS-CoV-2 neuronal invasion and complications: potential mechanisms and therapeutic approaches

O Swain, SK Romano, R Miryala, J Tsai… - Journal of …, 2021 - Soc Neuroscience
Clinical reports suggest that the coronavirus disease-19 (COVID-19) pandemic caused by
severe acute respiratory syndrome (SARS)-coronavirus-2 (CoV-2) has not only taken …

Gene signatures of SARS-CoV/SARS-CoV-2-infected ferret lungs in short-and long-term models

HL Liu, IJ Yeh, NN Phan, YH Wu, MC Yen… - Infection, Genetics and …, 2020 - Elsevier
Coronaviruses (CoVs) consist of six strains, and the severe acute respiratory syndrome
coronavirus (SARS-CoV), newly found coronavirus (SARS-CoV-2) has rapidly spread …