Cardio-onco-metabolism: metabolic remodelling in cardiovascular disease and cancer
Cardiovascular disease and cancer are the two leading causes of morbidity and mortality in
the world. The emerging field of cardio-oncology has revealed that these seemingly …
the world. The emerging field of cardio-oncology has revealed that these seemingly …
The relationship of redox with hallmarks of cancer: the importance of homeostasis and context
F Xing, Q Hu, Y Qin, J Xu, B Zhang, X Yu… - Frontiers in …, 2022 - frontiersin.org
Redox homeostasis is a lifelong pursuit of cancer cells. Depending on the context, reactive
oxygen species (ROS) exert paradoxical effects on cancers; an appropriate concentration …
oxygen species (ROS) exert paradoxical effects on cancers; an appropriate concentration …
An evolving view of complex II—noncanonical complexes, megacomplexes, respiration, signaling, and beyond
TM Iverson, PK Singh, G Cecchini - Journal of Biological Chemistry, 2023 - ASBMB
Mitochondrial complex II is traditionally studied for its participation in two key respiratory
processes: the electron transport chain and the Krebs cycle. There is now a rich body of …
processes: the electron transport chain and the Krebs cycle. There is now a rich body of …
Succinate dehydrogenase deficiency-driven succinate accumulation induces drug resistance in acute myeloid leukemia via ubiquitin-cullin regulation
Y Chen, M Xian, W Ying, J Liu, S Bing, X Wang… - Nature …, 2024 - nature.com
Drug resistance is vital for the poor prognosis of acute myeloid leukemia (AML) patients, but
the underlying mechanism remains poorly understood. Given the unique microenvironment …
the underlying mechanism remains poorly understood. Given the unique microenvironment …
[HTML][HTML] SDHi fungicides: An example of mitotoxic pesticides targeting the succinate dehydrogenase complex
CD Hospital, A Tête, K Debizet, J Imler… - Environment …, 2023 - Elsevier
Succinate dehydrogenase inhibitors (SDHi) are fungicides used to control the proliferation of
pathogenic fungi in crops. Their mode of action is based on blocking the activity of succinate …
pathogenic fungi in crops. Their mode of action is based on blocking the activity of succinate …
SDHB knockout and succinate accumulation are insufficient for tumorigenesis but dual SDHB/NF1 loss yields SDHx-like pheochromocytomas
N Armstrong, CM Storey, SE Noll, K Margulis, MH Soe… - Cell reports, 2022 - cell.com
Inherited pathogenic succinate dehydrogenase (SDHx) gene mutations cause the hereditary
pheochromocytoma and paraganglioma tumor syndrome. Syndromic tumors exhibit …
pheochromocytoma and paraganglioma tumor syndrome. Syndromic tumors exhibit …
Overview of recent guidelines and consensus statements on initial screening and management of phaeochromocytoma and paraganglioma in SDHx pathogenic …
C Lussey-Lepoutre, K Pacak, A Grossman… - Best Practice & …, 2024 - Elsevier
Phaeochromocytomas and paragangliomas (PPGLs) are rare neuroendocrine tumours with
a strong genetic predisposition, involving over 20 genes and with germline pathogenic …
a strong genetic predisposition, involving over 20 genes and with germline pathogenic …
Phenazine derivatives attenuate the stemness of breast cancer cells through triggering ferroptosis
Y Yang, Y Lu, C Zhang, Q Guo, W Zhang… - Cellular and Molecular …, 2022 - Springer
Breast cancer stem cells (BCSCs) are positively correlated with the metastasis,
chemoresistance, and recurrence of breast cancer. However, there are still no drugs …
chemoresistance, and recurrence of breast cancer. However, there are still no drugs …
Identification and validation of cuproptosis-related genes in acetaminophen-induced liver injury using bioinformatics analysis and machine learning
Z Guo, J Liu, G Liang, H Liang, M Zhong… - Frontiers in …, 2024 - frontiersin.org
Background Acetaminophen (APAP) is commonly used as an antipyretic analgesic.
However, acetaminophen overdose may contribute to liver injury and even liver failure …
However, acetaminophen overdose may contribute to liver injury and even liver failure …
A comprehensive characterisation of phaeochromocytoma and paraganglioma tumours through histone protein profiling, DNA methylation and transcriptomic analysis …
P Chatzikyriakou, D Brempou, M Quinn, L Fishbein… - Clinical …, 2023 - Springer
Abstract Background Phaeochromocytomas and paragangliomas (PPGLs) are rare
neuroendocrine tumours. Pathogenic variants have been identified in more than 15 …
neuroendocrine tumours. Pathogenic variants have been identified in more than 15 …