Diabetes mellitus is an increasingly prevalent chronic metabolic disease characterized by
prolonged hyperglycemia that leads to long-term health consequences. It is estimated that …

Epidermal growth factor (EGF) has been used in wound management and regenerative
medicine since the late 1980s. It has been widely utilized for a long time and still is because …

Management of chronic diabetic ulcers remains as a major challenge in healthcare which
requires extensive multidisciplinary approaches to ensure wound protection, management …

BACKGROUND Diabetic foot ulcers are a common diabetic complication leading to
alarming figures of amputation, disability, and early mortality. The diabetic glucooxidative …

Activated phosphatidylinositol 3 kinase/Protein kinase B (PI3K/AKT) signalling with
increased or reduced mTOR and GSK3β activity influences the wound repair process …

Introduction: Years of tissue engineering research have clearly demonstrated the potential of
integrating growth factors (GFs) into scaffolds for tissue regeneration, a concept that has …

Diabetic foot ulcers (DFUs) are characterized by a chronic inflammation state which prevents
cutaneous wound healing, and DFUs eventually lead to infection and leg amputation …

Purpose Impairment of wound healing is a major issue in type-2 diabetes that often causes
chronic infections, eventually leading to limb and/or organ amputation. Connective tissue …

Diabetes is constantly increasing at a rate that outpaces genetic variation and approaches to
pandemic magnitude. Skin cells physiology and the cutaneous healing response are …

Burns can be caused by various factors and have an increased risk of infection that can
seriously delay the wound healing process. Chronic wounds caused by burns represent a …