Clinical features of late-onset multiple sclerosis: a systematic review and meta-analysis

A Naseri, E Nasiri, MA Sahraian, S Daneshvar… - Multiple sclerosis and …, 2021 - Elsevier
Background Multiple sclerosis (MS) commonly affects young adults at the ages 20 to 40
years old, but it can onset at each age. Late-onset multiple sclerosis (LOMS) is defined as …

Late-onset MS: disease course and safety-efficacy of DMTS

MC Buscarinu, R Reniè, E Morena, C Romano… - Frontiers in …, 2022 - frontiersin.org
Multiple sclerosis (MS), an inflammatory demyelinating and neurodegenerative disease of
the central nervous system, usually begins between the ages of 20 and 49 years, though in …

Can coronavirus disease 2019 (COVID-19) trigger exacerbation of multiple sclerosis? A retrospective study

M Barzegar, S Vaheb, O Mirmosayyeb… - Multiple sclerosis and …, 2021 - Elsevier
The effect of coronavirus disease (COVID-19) on the risk of relapse in multiple sclerosis
(MS) have been unknown. In this retrospective study of 41 relapsing-remitting MS patients …

The ageing central nervous system in multiple sclerosis: the imaging perspective

M Filippi, P Preziosa, F Barkhof, O Ciccarelli… - Brain, 2024 - academic.oup.com
The interaction between ageing and multiple sclerosis is complex and carries significant
implications for patient care. Managing multiple sclerosis effectively requires an …

Current and future role of MRI in the diagnosis and prognosis of multiple sclerosis

MA Rocca, P Preziosa, F Barkhof… - The Lancet Regional …, 2024 - thelancet.com
In the majority of cases, multiple sclerosis (MS) is characterized by reversible episodes of
neurological dysfunction, often followed by irreversible clinical disability. Accurate diagnostic …

Early predictors of conversion to secondary progressive multiple sclerosis

M Barzegar, S Najdaghi, A Afshari-Safavi… - Multiple sclerosis and …, 2021 - Elsevier
Background: We conducted this study to estimated the time of conversion from relapsing-
remitting MS (RRMS) to SPMS and its early predictor factors. Methods: In this retrospective …

CNS border-associated macrophages: ontogeny and potential implication in disease

I Dermitzakis, P Theotokis, P Evangelidis… - Current Issues in …, 2023 - mdpi.com
Being immune privileged, the central nervous system (CNS) is constituted by unique
parenchymal and non-parenchymal tissue-resident macrophages, namely, microglia and …

Comparing the Pathology, Clinical, and Demographic Characteristics of Younger and Older‐Onset Multiple Sclerosis

S Knowles, R Middleton, B Cooze, I Farkas… - Annals of …, 2024 - Wiley Online Library
Objective Older people with multiple sclerosis (MS) have a less active radiological and
clinical presentation, but many still attain significant levels of disability; but what drives …

Current knowledge on multiple sclerosis pathophysiology, disability progression assessment and treatment options, and the role of autologous hematopoietic stem …

G Gakis, I Angelopoulos, I Panagoulias… - Autoimmunity Reviews, 2024 - Elsevier
Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS) that
affects nearly 2.8 million people each year. MS distinguishes three main types: relapsing …

Epidemiology of familial multiple sclerosis in Iran: a national registry-based study

Z Salehi, A Almasi-Hashiani, MA Sahraian, F Ashtari… - BMC neurology, 2022 - Springer
Background Admittedly, little is known about the epidemiological signatures of familial
multiple sclerosis (FMS) in different geographical regions of Iran. Objective To determine the …