Bacterial biofilm and its role in the pathogenesis of disease

LK Vestby, T Grønseth, R Simm, LL Nesse - Antibiotics, 2020 - mdpi.com
Recognition of the fact that bacterial biofilm may play a role in the pathogenesis of disease
has led to an increased focus on identifying diseases that may be biofilm-related. Biofilm …

Urinary tract infections: microbial pathogenesis, host–pathogen interactions and new treatment strategies

RD Klein, SJ Hultgren - Nature Reviews Microbiology, 2020 - nature.com
Urinary tract infections (UTIs) are common, recurrent infections that can be mild to life-
threatening. The continued emergence of antibiotic resistance, together with our increasing …

Recurrent urinary tract infection: a mystery in search of better model systems

BO Murray, C Flores, C Williams… - Frontiers in cellular …, 2021 - frontiersin.org
Urinary tract infections (UTIs) are among the most common infectious diseases worldwide
but are significantly understudied. Uropathogenic E. coli (UPEC) accounts for a significant …

Importance of biofilms in urinary tract infections: new therapeutic approaches

SM Soto - Advances in biology, 2014 - Wiley Online Library
Bacterial biofilms play an important role in urinary tract infections (UTIs), being responsible
for persistence infections causing relapses and acute prostatitis. Bacterial forming biofilm …

Microbial biofilms in urinary tract infections and prostatitis: Etiology, pathogenicity, and combating strategies

C Delcaru, I Alexandru, P Podgoreanu, M Grosu… - Pathogens, 2016 - mdpi.com
Urinary tract infections (UTIs) are one of the most important causes of morbidity and health
care spending affecting persons of all ages. Bacterial biofilms play an important role in UTIs …

Drug and vaccine development for the treatment and prevention of urinary tract infections

VP O'brien, TJ Hannan, HV Nielsen… - Urinary Tract Infections …, 2017 - Wiley Online Library
Urinary tract infections (UTI) are one of the most common bacterial infections, with roughly
eleven‐million cases reported in the US each year that cost an estimated $5 billion annually …

Dynamic persistence of UPEC intracellular bacterial communities in a human bladder-chip model of urinary tract infection

K Sharma, N Dhar, VV Thacker, TM Simonet… - Elife, 2021 - elifesciences.org
Uropathogenic Escherichia coli (UPEC) proliferate within superficial bladder umbrella cells
to form intracellular bacterial communities (IBCs) during early stages of urinary tract …

A human urothelial microtissue model reveals shared colonization and survival strategies between uropathogens and commensals

C Flores, J Ling, A Loh, RG Maset, A Aw, IJ White… - Science …, 2023 - science.org
Urinary tract infection is among the most common infections worldwide, typically studied in
animals and cell lines with limited uropathogenic strains. Here, we assessed diverse …

Virulence factors of uropathogenic E. coli and their interaction with the host

P Lüthje, A Brauner - Advances in microbial physiology, 2014 - Elsevier
Urinary tract infections (UTIs) belong to the most common infectious diseases worldwide.
The most frequently isolated pathogen from uncomplicated UTIs is Escherichia coli. To …

Bacterial virulence phenotypes of Escherichia coli and host susceptibility determine risk for urinary tract infections

HL Schreiber IV, MS Conover, WC Chou… - Science translational …, 2017 - science.org
Urinary tract infections (UTIs) are caused by uropathogenic Escherichia coli (UPEC) strains.
In contrast to many enteric E. coli pathogroups, no genetic signature has been identified for …