Mammalian ABC transporters in health and disease

P Borst, RO Elferink - Annual review of biochemistry, 2002 - annualreviews.org
▪ Abstract The ATP-binding cassette (ABC) transporters are a family of large proteins in
membranes and are able to transport a variety of compounds through membranes against …

Intrahepatic cholestasis of pregnancy: molecular pathogenesis, diagnosis and management

F Lammert, HU Marschall, A Glantz… - Journal of …, 2000 - journal-of-hepatology.eu
C or impaired bile flow, is one of the most common and devastating manifestations of
hereditary and acquired liver diseases. Intrahepatic cholestasis of pregnancy (ICP) is a …

Extraction of cholesterol with methyl-β-cyclodextrin perturbs formation of clathrin-coated endocytic vesicles

SK Rodal, G Skretting, Ø Garred… - Molecular biology of …, 1999 - Am Soc Cell Biol
The importance of cholesterol for endocytosis has been investigated in HEp-2 and other cell
lines by using methyl-β-cyclodextrin (MβCD) to selectively extract cholesterol from the …

[HTML][HTML] Cardioprotective effects of dietary polyphenols

TL Zern, ML Fernandez - The Journal of nutrition, 2005 - Elsevier
Dietary polyphenols have been shown to possess cardioprotective effects. For example, the
most noted role of grape polyphenols is in the French Paradox, in which a diet high in …

Multifunctionality of plant ABC transporters–more than just detoxifiers

E Martinoia, M Klein, M Geisler, L Bovet, C Forestier… - Planta, 2002 - Springer
The ABC-transporter superfamily is one of the largest protein families, and members can be
found in bacteria, fungi, plants and animals. The first reports on plant ABC transporters …

Intrahepatic cholestasis of pregnancy

T Pusl, U Beuers - Orphanet journal of rare diseases, 2007 - Springer
Intrahepatic cholestasis of pregnancy (ICP) is a cholestatic disorder characterized by (i)
pruritus with onset in the second or third trimester of pregnancy,(ii) elevated serum …

Cholesterol is required for surface transport of influenza virus hemagglutinin

P Keller, K Simons - The Journal of cell biology, 1998 - rupress.org
Transport from the TGN to the basolateral surface involves a rab/N-ethylmaleimide–sensitive
fusion protein (NSF)/soluble NSF attachment protein (SNAP)/SNAP receptor (SNARE) …

Multiple physiological functions for multidrug transporter P-glycoprotein?

RW Johnstone, AA Ruefli, MJ Smyth - Trends in biochemical sciences, 2000 - cell.com
Multidrug resistance mediated by the drug-efflux protein P-glycoprotein (P-gp) is one
mechanism that tumor cells use to escape death induced by chemotherapeutic drugs …

Intracellular cholesterol transport

L Liscum, NJ Munn - Biochimica et Biophysica Acta (BBA)-Molecular and …, 1999 - Elsevier
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Human white/murine ABC8 mRNA levels are highly induced in lipid-loaded macrophages: a transcriptional role for specific oxysterols

A Venkateswaran, JJ Repa, JMA Lobaccaro… - Journal of Biological …, 2000 - ASBMB
To identify genes that are transcriptionally activated when human macrophages accumulate
excess lipids, we employed the mRNA differential display technique using RNA isolated …