Human organoid models to study SARS-CoV-2 infection
Abstract Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) is one of the deadliest pandemics in history. SARS …
syndrome coronavirus 2 (SARS-CoV-2) is one of the deadliest pandemics in history. SARS …
Recent progress toward the discovery of small molecules as novel anti-respiratory syncytial virus agents
T Felicetti, C Sarnari, R Gaito, O Tabarrini… - Journal of Medicinal …, 2024 - ACS Publications
Respiratory syncytial virus (RSV) stands as the foremost cause of infant hospitalization
globally, ranking second only to malaria in terms of infant mortality. Although three vaccines …
globally, ranking second only to malaria in terms of infant mortality. Although three vaccines …
A broad antiviral strategy: inhibitors of human DHODH pave the way for host-targeting antivirals against emerging and re-emerging viruses
Y Zheng, S Li, K Song, J Ye, W Li, Y Zhong, Z Feng… - Viruses, 2022 - mdpi.com
New strategies to rapidly develop broad-spectrum antiviral therapies are urgently required
for emerging and re-emerging viruses. Host-targeting antivirals (HTAs) that target the …
for emerging and re-emerging viruses. Host-targeting antivirals (HTAs) that target the …
Synthesis of SARS-CoV-2 M pro inhibitors bearing a cinnamic ester warhead with in vitro activity against human coronaviruses
A Citarella, D Moi, M Pedrini, H Pérez-Peña… - Organic & …, 2023 - pubs.rsc.org
COVID-19 now ranks among the most devastating global pandemics in history. The
causative virus, SARS-CoV-2, is a new human coronavirus (hCoV) that spreads among …
causative virus, SARS-CoV-2, is a new human coronavirus (hCoV) that spreads among …
A multi-organoid platform identifies CIART as a key factor for SARS-CoV-2 infection
COVID-19 is a systemic disease involving multiple organs. We previously established a
platform to derive organoids and cells from human pluripotent stem cells to model SARS …
platform to derive organoids and cells from human pluripotent stem cells to model SARS …
Development trends of human organoid‐based COVID‐19 research based on bibliometric analysis
M Li, Y Yuan, T Zou, Z Hou, L Jin, B Wang - Cell Proliferation, 2023 - Wiley Online Library
Abstract Coronavirus disease 2019 (COVID‐19), a global pandemic caused by the severe
acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), has posed a catastrophic threat …
acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), has posed a catastrophic threat …
[HTML][HTML] Organoid studies in COVID-19 research
The current COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus
2 (SARS-CoV-2) has completely changed human life for more than two years. Upon the …
2 (SARS-CoV-2) has completely changed human life for more than two years. Upon the …
Targeting Acute Myelogenous Leukemia Using Potent Human Dihydroorotate Dehydrogenase Inhibitors Based on the 2-Hydroxypyrazolo[1,5-a]pyridine Scaffold …
S Sainas, M Giorgis, P Circosta… - Journal of Medicinal …, 2021 - ACS Publications
The connection with acute myelogenous leukemia (AML) of dihydroorotate dehydrogenase
(h DHODH), a key enzyme in pyrimidine biosynthesis, has attracted significant interest from …
(h DHODH), a key enzyme in pyrimidine biosynthesis, has attracted significant interest from …
Inhibitors of nucleotide biosynthesis as candidates for a wide spectrum of antiviral chemotherapy
CS Sepúlveda, CC García, EB Damonte - Microorganisms, 2022 - mdpi.com
Emerging and re-emerging viruses have been a challenge in public health in recent
decades. Host-targeted antivirals (HTA) directed at cellular molecules or pathways involved …
decades. Host-targeted antivirals (HTA) directed at cellular molecules or pathways involved …
Inhibitors of dihydroorotate dehydrogenase cooperate with molnupiravir and N4-hydroxycytidine to suppress SARS-CoV-2 replication
KM Stegmann, A Dickmanns, N Heinen, C Blaurock… - Iscience, 2022 - cell.com
The nucleoside analog N4-hydroxycytidine (NHC) is the active metabolite of the prodrug
molnupiravir, which has been approved for the treatment of COVID-19. SARS-CoV-2 …
molnupiravir, which has been approved for the treatment of COVID-19. SARS-CoV-2 …