A concept of welfare based on reward evaluating mechanisms in the brain: anticipatory behaviour as an indicator for the state of reward systems
In this review we attempt to link the efficiency by which animals behave (economy of animal
behaviour) to a neuronal substrate and subjective states to arrive at a definition of animal …
behaviour) to a neuronal substrate and subjective states to arrive at a definition of animal …
Regulation of opioid tolerance by let-7 family microRNA targeting the μ opioid receptor
Y He, C Yang, CM Kirkmire, ZJ Wang - Journal of Neuroscience, 2010 - Soc Neuroscience
MicroRNA has emerged as a critical regulator of neuronal functions. This study aimed to test
whether let-7 microRNAs can regulate the μ opioid receptor (MOR) and opioid tolerance …
whether let-7 microRNAs can regulate the μ opioid receptor (MOR) and opioid tolerance …
Opiate tolerance and dependence: receptors, G-proteins, and antiopiates
LM Harrison, AJ Kastin, JE Zadina - Peptides, 1998 - Elsevier
Despite the existence of a large body of information on the subject, the mechanisms of
opiate tolerance and dependence are not yet fully understood. Although the traditional …
opiate tolerance and dependence are not yet fully understood. Although the traditional …
Acute opioid receptor desensitization and tolerance: is there a link?
SL Borgland - Clinical and Experimental Pharmacology and …, 2001 - Wiley Online Library
Morphine, used long‐term for the treatment of pain, results in drug tolerance. The
therapeutic benefits, as well as side effects, of morphine are mediated predominantly via …
therapeutic benefits, as well as side effects, of morphine are mediated predominantly via …
The effect of repeated administration of morphine, cocaine and ethanol on mu and delta opioid receptor density in the nucleus accumbens and striatum of the rat
J Turchan, B Przewłocka, G Toth, W Lasoń, A Borsodi… - Neuroscience, 1999 - Elsevier
The present study was carried out to evaluate the effect of morphine, cocaine and ethanol on
the density of opioid receptors in the nucleus accumbens and striatum of rat brain. The …
the density of opioid receptors in the nucleus accumbens and striatum of rat brain. The …
Opioid abuse and brain gene expression
R Przewlocki - European journal of pharmacology, 2004 - Elsevier
Opiate addiction is a central nervous system disorder of unknown mechanism. Neuronal
basis of positive reinforcement, which is essential to the action of opioids, relies on activation …
basis of positive reinforcement, which is essential to the action of opioids, relies on activation …
μ-Opioid receptor down-regulation and cAMP-dependent protein kinase phosphorylation in a mouse model of chronic morphine tolerance
MA Bernstein, SP Welch - Molecular brain research, 1998 - Elsevier
Results of radioligand binding and transfected receptor studies indicate that μ-receptor
down-regulation and phosphorylation may be critical to the expression of morphine …
down-regulation and phosphorylation may be critical to the expression of morphine …
Expression of calcitonin gene-related peptide, substance P and protein kinase C in cultured dorsal root ganglion neurons following chronic exposure to mu, delta and …
S Belanger, W Ma, JG Chabot, R Quirion - Neuroscience, 2002 - Elsevier
The mechanisms involved in morphine tolerance are poorly understood. It was reported by
our group that calcitonin gene-related peptide (CGRP)-like immunoreactivity (IR) was …
our group that calcitonin gene-related peptide (CGRP)-like immunoreactivity (IR) was …
Shanzhiside methylester, the principle effective iridoid glycoside from the analgesic herb Lamiophlomis rotata, reduces neuropathic pain by stimulating spinal …
Lamiophlomis rotata (L. rotata, Duyiwei) is an orally available Tibetan analgesic herb widely
prescribed in China. Shanzhiside methylester (SM) is a principle effective iridoid glycoside …
prescribed in China. Shanzhiside methylester (SM) is a principle effective iridoid glycoside …