Introduction: Insulin secretory defects are a key feature in the pathophysiology of type 2
diabetes (T2D). Classical insulin-secreting agents such as sulfonlyureas stimulate insulin …

Metabolic disorders, such as insulin resistance, affect many people worldwide due to the
prevalence of obesity and type 2 diabetes, which are pathologies that impair glycemic …

Objective Defective glucose uptake in adipocytes leads to impaired metabolic homeostasis
and insulin resistance, hallmarks of type 2 diabetes. Extracellular ATP-derived nucleotides …

摘要在胰岛β 细胞中, 线粒体内的三磷酸腺苷(Adenosine triphosphate, ATP)
的合成及分泌对调控胰岛素分泌起重要作用. ATP 合成速率降低是线粒体功能障碍的主要表现 …

So far, the mechanism that links mitochondrial dysfunction to PDX1 inhibition in the
pathogenesis of pancreatic β cell dysfunction under diabetic condition remains largely …

Production of adenosine in the extracellular tumor microenvironment elicits strong
immunosuppression and is associated with tumor progression. Thus, targeting adenosine …

Type 2 diabetes mellitus (T2DM) is characterized by peripheral insulin resistance and an
insufficiency of insulin secretion from the pancreatic β cell. The incidence of T2DM is rising …

O receptor P2X7 (P2X7R) é um canal iônico expresso principalmente em células do sistema
imune e está envolvido em processos celulares como inflamação, morte celular e dor. Em …