Ubiquitin-like protein conjugation: structures, chemistry, and mechanism
L Cappadocia, CD Lima - Chemical reviews, 2018 - ACS Publications
Ubiquitin-like proteins (Ubl's) are conjugated to target proteins or lipids to regulate their
activity, stability, subcellular localization, or macromolecular interactions. Similar to ubiquitin …
activity, stability, subcellular localization, or macromolecular interactions. Similar to ubiquitin …
Ubiquitin-like proteins
AG van der Veen, HL Ploegh - Annual review of biochemistry, 2012 - annualreviews.org
The eukaryotic ubiquitin family encompasses nearly 20 proteins that are involved in the
posttranslational modification of various macromolecules. The ubiquitin-like proteins (UBLs) …
posttranslational modification of various macromolecules. The ubiquitin-like proteins (UBLs) …
Mechanism and inhibition of the papain‐like protease, PLpro, of SARS‐CoV‐2
T Klemm, G Ebert, DJ Calleja, CC Allison… - The EMBO …, 2020 - embopress.org
The SARS‐CoV‐2 coronavirus encodes an essential papain‐like protease domain as part of
its non‐structural protein (nsp)‐3, namely SARS2 PLpro, that cleaves the viral polyprotein …
its non‐structural protein (nsp)‐3, namely SARS2 PLpro, that cleaves the viral polyprotein …
On terminal alkynes that can react with active-site cysteine nucleophiles in proteases
Active-site directed probes are powerful in studies of enzymatic function. We report an active-
site directed probe based on a warhead so far considered unreactive. By replacing the C …
site directed probe based on a warhead so far considered unreactive. By replacing the C …
[HTML][HTML] ISG15: it's complicated
JV Dzimianski, FEM Scholte, É Bergeron… - Journal of molecular …, 2019 - Elsevier
Interferon-stimulated gene product 15 (ISG15) is a key component of host responses to
microbial infection. Despite having been known for four decades, grasping the functions and …
microbial infection. Despite having been known for four decades, grasping the functions and …
Structural basis for the ubiquitin-linkage specificity and deISGylating activity of SARS-CoV papain-like protease
Severe acute respiratory syndrome coronavirus (SARS-CoV) encodes a papain-like
protease (PLpro) with both deubiquitinating (DUB) and deISGylating activities that are …
protease (PLpro) with both deubiquitinating (DUB) and deISGylating activities that are …
The mechanism of OTUB1-mediated inhibition of ubiquitination
R Wiener, X Zhang, T Wang, C Wolberger - Nature, 2012 - nature.com
Histones are ubiquitinated in response to DNA double-strand breaks (DSB), promoting
recruitment of repair proteins to chromatin. UBC13 (also known as UBE2N) is a ubiquitin …
recruitment of repair proteins to chromatin. UBC13 (also known as UBE2N) is a ubiquitin …
Recent advances in the molecular and cellular biology of bunyaviruses
The family Bunyaviridae of segmented, negative-stranded RNA viruses includes over 350
members that infect a bewildering variety of animals and plants. Many of these bunyaviruses …
members that infect a bewildering variety of animals and plants. Many of these bunyaviruses …
Potential inhibitors targeting papain-like protease of SARS-CoV-2: two birds with one stone
H Jiang, P Yang, J Zhang - Frontiers in chemistry, 2022 - frontiersin.org
Severe acute respiratory syndrome Coronavirus-2 (SARS-CoV-2), the pathogen of the
Coronavirus disease-19 (COVID-19), is still devastating the world causing significant chaos …
Coronavirus disease-19 (COVID-19), is still devastating the world causing significant chaos …
[HTML][HTML] Recent advances in understanding Crimean–Congo hemorrhagic fever virus
DW Hawman, H Feldmann - F1000Research, 2018 - ncbi.nlm.nih.gov
Crimean-Congo hemorrhagic fever virus (CCHFV) is a widely distributed hemorrhagic fever
virus and the cause of hemorrhagic disease in Africa, Southern and Eastern Europe, the …
virus and the cause of hemorrhagic disease in Africa, Southern and Eastern Europe, the …