Adult epilepsy

JS Duncan, JW Sander, SM Sisodiya, MC Walker - The Lancet, 2006 - thelancet.com
The epilepsies are one of the most common serious brain disorders, can occur at all ages,
and have many possible presentations and causes. Although incidence in childhood has …

Genetic landscape of common epilepsies: advancing towards precision in treatment

S Thakran, D Guin, P Singh, P Singh, S Kukal… - International journal of …, 2020 - mdpi.com
Epilepsy, a neurological disease characterized by recurrent seizures, is highly
heterogeneous in nature. Based on the prevalence, epilepsy is classified into two types …

[HTML][HTML] Molecular targets for antiepileptic drug development

BS Meldrum, MA Rogawski - Neurotherapeutics, 2007 - Elsevier
This review considers how recent advances in the physiology of ion channels and other
potential molecular targets, in conjunction with new information on the genetics of idiopathic …

Neurons that fire together also conspire together: is normal sleep circuitry hijacked to generate epilepsy?

MP Beenhakker, JR Huguenard - Neuron, 2009 - cell.com
Neurons that Fire Together Also Conspire Together: Is Normal Sleep Circuitry Hijacked to
Generate Epilepsy?: Neuron Skip to Main Content Advertisement Neuron This journal offers …

Cellular and network mechanisms of spike‐wave seizures

H Blumenfeld - Epilepsia, 2005 - Wiley Online Library
Spike‐wave seizures are often considered a relatively “pure” form of epilepsy, with a uniform
defect present in all patients and involvement of the whole brain homogenously. Here, we …

Meta-analysis identifies seven susceptibility loci involved in the atopic march

I Marenholz, J Esparza-Gordillo, F Rüschendorf… - Nature …, 2015 - nature.com
Eczema often precedes the development of asthma in a disease course called the 'atopic
march'. To unravel the genes underlying this characteristic pattern of allergic disease, we …

Epilepsy genetics: current knowledge, applications, and future directions

KA Myers, DL Johnstone, DA Dyment - Clinical genetics, 2019 - Wiley Online Library
The rapid pace of disease gene discovery has resulted in tremendous advances in the field
of epilepsy genetics. Clinical testing with comprehensive gene panels, exomes, and …

Familial risk of epilepsy: a population-based study

AL Peljto, C Barker-Cummings, VM Vasoli, CL Leibson… - Brain, 2014 - academic.oup.com
Almost all previous studies of familial risk of epilepsy have had potentially serious
methodological limitations. Our goal was to address these limitations and provide more …

A whole-genome scan and fine-mapping linkage study of auditory-visual synesthesia reveals evidence of linkage to chromosomes 2q24, 5q33, 6p12, and 12p12

JE Asher, JA Lamb, D Brocklebank, JB Cazier… - The American Journal of …, 2009 - cell.com
Synesthesia, a neurological condition affecting between 0.05%–1% of the population, is
characterized by anomalous sensory perception and associated alterations in cognitive …

Genetic testing in the epilepsies—report of the ILAE Genetics Commission

R Ottman, S Hirose, S Jain, H Lerche, I Lopes‐Cendes… - 2010 - Wiley Online Library
In this report, the International League Against Epilepsy (ILAE) Genetics Commission
discusses essential issues to be considered with regard to clinical genetic testing in the …