Cell migration is central to the development and maintenance of multicellular organisms.
Fundamental understanding of cell migration can, for example, direct novel therapeutic …

Cells are highly dynamic and mechanical automata powered by molecular motors that
respond to external cues. Intracellular signaling pathways, either chemical or mechanical …

Glioblastoma (GBM) prognosis remains dismal due in part to the invasiveness of GBM cells.
Interstitial fluid flow (IFF) has been shown to increase invasion of glioma cells in vitro …

The cancer cells obtain their invasion potential not only by genetic mutations, but also by
changing their cellular biophysical and biomechanical features and adapting to the …

Cell migration on a two-dimensional flat surface has been extensively studied and is
generally characterized by a front-protrusion–rear-contraction process. In a three …

Cellular cytoskeletal mechanics plays a major role in many aspects of human health from
organ development to wound healing, tissue homeostasis and cancer metastasis. We …

Cells are a fundamental structural, functional and biological unit for all living organisms. Up
till now, considerable efforts have been made to study the responses of single cells and …

Mechanical signals exist throughout the biological landscape. Across all scales, these
signals, in the form of force, stiffness, and deformations, are generated and processed …

Cell migration plays an essential role in cancer metastasis. In cancer invasion through
confined spaces, cells must undergo extensive deformation, which is a capability related to …

In this work, we develop a mathematical formalism based on a 3D in vitro model that is used
to simulate the early stages of angiogenesis. The model treats cells as individual entities that …