BackgroundOver the past 10 years the technique of tryptophan depletion has been used
increasingly as a tool for studying brain serotonergic systems. AimsTo review the technique …

The wide use of serotonin reuptake inhibitors and serotonin receptor agonists in anxiety
disorders has suggested a key role for the modulatory neurotransmitter in anxiety. However …

BACKGROUND: Treatments for obsessive-compulsive disorder (OCD) usually lead to
incomplete symptom relief and take a long-time to reach full effect. Convergent evidence …

Selective serotonin reuptake inhibitors (SSRIs) have demonstrated efficacy in depression
and anxiety disorders. This raises the question of how the single action of serotonin …

We review here the rapid tryptophan depletion (RTD) methodology and its controversial
association with depressive relapse. RTD has been used over the past decade to deplete …

Background: The number of studies using tryptophan depletion (TD) challenge has
increased markedly in the past few years. Recently, a number of negative results have been …

Objective Recent studies have raised the question as to whether a dysregulation of the
neurotransmitter serotonin may contribute to the alterations in mood seen in anorexia …

Работа посвящена актуальной проблеме часто встречающихся в клинической практике
больных с сочетанием тревожной и депрессивной симптоматики. Рассматриваются …

Evidence that the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT) plays a role in the
pathophysiology of mood disorders has been accumulating over the past three decades …

Objective: This is the second of two articles reviewing the modern dietary technique of acute
tryptophan depletion (ATD), a method of transiently reducing central serotonin levels in both …