Recent advances in clinical protocols have improved the outcomes of pancreatic islet
transplantation (PIT), yet PIT recipients typically require pancreatic islet grafts derived from …

Endogenous pancreatic islets have a dense glomerular-like angioarchitecture, which
ensures an optimal delivery of oxygen and nutrients to the islet cells, provides signals from …

An adequate revascularization is crucial for islet survival and function after transplantation.
Previous studies have suggested that islet revascularization is concluded within 14 days …

Pancreatic islets are avascular immediately after transplantation. Although the islets are
rapidly revascularized, it is uncertain whether the revascularization produces an adequate …

A considerable number of experimental studies have demonstrated that the reestablishment
of an appropriate microvascular supply is an essential prerequisite for successful pancreatic …

Background. A factor of potential importance in the failure of islet grafts is poor or inadequate
engraftment of the islets in the implantation organ. This study measured the oxygen tension …

Background. Delayed angiogenesis remains a significant challenge to the survival of
transplanted islets. In this study, using a murine model of subcutaneous islet transplantation …

Microcirculatory derangements in organ transplantation, characterized by capillary perfusion
failure and inflammation‐associated leukocyte recruitment, are major determinants for the …

Aims/hypothesis Recent studies suggest that donor endothelial cells may contribute to islet
graft revascularisation. Since islet endothelial cells disappear during culture, we …

Aims Immunosuppressive drugs could be crucial factors for a poor outcome after islet
allotransplantation. Unlike rapamycin, the effects of tacrolimus, the current standard …