The self-renewal capacity of multipotent haematopoietic stem cells (HSCs) supports blood
system homeostasis throughout life and underlies the curative capacity of clinical HSC …

Every year, cancer claims millions of lives around the globe. Unfortunately, model systems
that accurately mimic human oncology–a requirement for the development of more effective …

Sickle cell disease (SCD) is caused by a mutation in the β-globin gene HBB. We used a
custom adenine base editor (ABE8e-NRCH), to convert the SCD allele (HBB S) into …

Multipotent self-renewing haematopoietic stem cells (HSCs) regenerate the adult blood
system after transplantation, which is a curative therapy for numerous diseases including …

Host microbiota crosstalk is essential for the production and functional modulation of blood-
cell lineages. Whether, and if so how, the microbiota influences hematopoietic stem cells …

Maintaining proteostasis is key to resisting stress and promoting healthy aging. Proteostasis
is necessary to preserve stem cell function, but little is known about the mechanisms that …

Clinical transplants of hematopoietic stem cells (HSC) can provide a lifesaving therapy for
many hematological diseases; however, therapeutic applications are hampered by donor …

Hematopoietic stem cells (HSCs) balance self-renewal and differentiation to maintain
homeostasis. With aging, the frequency of polar HSCs decreases. Cell polarity in HSCs is …

The contribution of endocardial cells (EdCs) to the hematopoietic lineages has been
strongly debated. Here, we provide evidence that in zebrafish, the endocardium gives rise to …

Hematopoietic stem cells (HSCs) are fundamental to the generation of the body's blood and
immune cells. They reside primarily within the bone marrow (BM) niche microenvironment …