Allogeneic hematopoietic SCT (HSCT) is an established treatment for some children with life-
threatening hematological disease, immune deficiencies and inborn errors of metabolism …

Pharmacogenetics represents an exciting, new promising tool for the individualisation of
therapy. Several genetic polymorphisms and haplotypes have been considered in an …

Individual differences in drug efficacy or toxicity can be influenced by genetic factors. We
investigated whether polymorphisms of pharmacogenes that interfere with metabolism of …

Candidate genetic associations with acute GVHD (aGVHD) were evaluated with the use of
genotyped and imputed single-nucleotide polymorphism data from genome-wide scans of …

The 5, 10-methylenetetrahydrofolate reductase (MTHFR) is a key enzyme for intracellular
folate homeostasis and metabolism. Two common MTHFR polymorphisms, C677T and …

Objective A systematic review and a meta-analysis were conducted, to investigate the
possible association of methylene tetrahydrofolate reductase (MTHFR) gene polymorphisms …

Identifying genetic factors associated with the development of adverse events might allow
screening before vaccinia virus administration. Two independent clinical trials of the …

Hematopoietic stem cell transplantation (HSCT) is a procedure in which infusion of
hematopoietic stem cells is used to reestablish hematopoietic function in patients with …

Despite optimal supportive care and high-resolution HLA matching, complications such as
GVHD and infection remain major barriers to the success of allogeneic HCT (allo-HCT). This …

Methylenetetrahydrofolate reductase (MTHFR) and thymidylate synthase (TS) play key roles
in intracellular folate metabolism. Polymorphisms in these enzymes have been shown to …