Fluorescence imaging techniques play a pivotal role in our understanding of the nervous
system. The emergence of various super-resolution microscopy methods and specialized …

The function of brain circuits relies on high-fidelity information transfer within neurons.
Synaptic inputs arrive primarily at dendrites, where they undergo integration and summation …

Synapses are minuscule, intricate structures crucial for the correct communication between
neurons. In the 125 years since the term synapse was first coined, we have advanced a long …

Array tomography encompasses light and electron microscopy modalities that offer
unparalleled opportunities to explore three-dimensional cellular architectures in extremely …

We investigated the genome of a 5-year-old male who presented with global developmental
delay (motor, cognitive, and speech), hypotonia, possibly ataxia, and cerebellar hypoplasia …

The transcriptome analysis of injured Xenopus laevis tadpole and mice suggested that
Neurod4L. S., a basic-helix-loop-helix transcription factor, was the most promising …

Fragile X syndrome (FXS) is the most common form of intellectual disability that arises from
the dysfunction of a single gene—Fmr1. The main neuroanatomical correlate of FXS is …

Fragile X syndrome (FXS) is caused by the loss of fragile X messenger ribonucleoprotein
(FMRP), a translational regulator that binds the transcripts of proteins involved in synaptic …

Deeper exploration of the brain's vast synaptic networks will require new tools for high-
throughput structural and molecular profiling of the diverse populations of synapses that …

The array tomography (AT) approach offers several important advantages for correlative
microscopy. In AT, a three‐dimensional biological sample is reduced to a two‐dimensional …