Recent progress of targeted G-quadruplex-preferred ligands toward cancer therapy

S Asamitsu, S Obata, Z Yu, T Bando, H Sugiyama - Molecules, 2019 - mdpi.com
A G-quadruplex (G4) is a well-known nucleic acid secondary structure comprising guanine-
rich sequences, and has profound implications for various pharmacological and biological …

Natural and Synthetic Chromenes, Fused Chromenes, and Versatility of Dihydrobenzo[h]chromenes in Organic Synthesis

R Pratap, VJ Ram - Chemical reviews, 2014 - ACS Publications
1. INTRODUCTION Bicyclic oxygen heterocycles resulting from fusion of benzene ring with
5, 6-positions of either 2H-or 4H-pyran ring system are designated as 2H-chromene (2H-1 …

Helicenes: synthesis and applications

Y Shen, CF Chen - Chemical reviews, 2012 - ACS Publications
Helicenes are polycyclic aromatic compounds with nonplanar screw-shaped skeletons
formed by ortho-fused benzene or other aromatic rings. 1, 2 The first helicenes 1 and 2 …

One hundred years of helicene chemistry. Part 3: applications and properties of carbohelicenes

M Gingras - Chemical Society Reviews, 2013 - pubs.rsc.org
Carbohelicenes are a class of fascinating chiral helical molecules which have a rich history
in chemistry. Over a period of almost 100 years, chemists have developed many methods to …

[HTML][HTML] Multimeric G-quadruplexes: A review on their biological roles and targeting

I Frasson, V Pirota, SN Richter, F Doria - International Journal of Biological …, 2022 - Elsevier
In human cells, nucleic acids adopt several non-canonical structures that regulate key
cellular processes. Among them, G-quadruplexes (G4s) are stable structures that form in …

G-quadruplex DNA: a longer story

RC Monsen, JO Trent, JB Chaires - Accounts of chemical …, 2022 - ACS Publications
Conspectus G-quadruplexes (G4s) are distinctive four-stranded DNA or RNA structures
found within cells that are thought to play functional roles in gene regulation and …

The fixed propeller-like conformation of tetraphenylethylene that reveals aggregation-induced emission effect, chiral recognition, and enhanced chiroptical property

JB Xiong, HT Feng, JP Sun, WZ Xie… - Journal of the …, 2016 - ACS Publications
The propeller-like conformation of tetraphenylethylene (TPE) with aggregation-induced
emission (AIE) effect was partially and completely fixed by intramolecular cyclization for the …

Ligand design to acquire specificity to intended G‐quadruplex structures

S Asamitsu, T Bando… - Chemistry–A European …, 2019 - Wiley Online Library
AG‐quadruplex is a nucleic acid secondary structure that is adopted by guanine‐rich
sequences, and is considered to be relevant in various pharmacological and biological …

Catalytic enantioselective synthesis of helicenes

W Liu, T Qin, W Xie, X Yang - Chemistry–A European Journal, 2022 - Wiley Online Library
Helicenes and helicene‐like molecules, usually containing multiple ortho‐fused aromatic
rings, possess unique helical chirality. These compounds have found a wide range of …

Nitrogen-embedded quintuple [7] helicene: a helicene–azacorannulene hybrid with strong near-infrared fluorescence

YF Wu, SW Ying, LY Su, JJ Du, L Zhang… - Journal of the …, 2022 - ACS Publications
Herein, a nitrogen-embedded quintuple [7] helicene (N-Q7H) with an
azapentabenzocorannulene core, which can be considered to be a helicene …