The locus coeruleus (LC), or 'blue spot', is a small nucleus located deep in the brainstem
that provides the far-reaching noradrenergic neurotransmitter system of the brain. This …

The release of the neurotransmitter norepinephrine throughout the mammalian brain is
important for modulating attention, arousal, and cognition during many behaviors …

The locus coeruleus noradrenergic (LC-NE) system is one of the first systems engaged
following a stressful event. While numerous groups have demonstrated that LC-NE neurons …

Arousal may be understood on a spectrum, with excessive sleepiness, cognitive dysfunction,
and inattention on one side, a wakeful state in the middle, and hypervigilance, panic, and …

It has been known for decades that degeneration of the locus coeruleus (LC), the major
noradrenergic nucleus in the brain, occurs in both Alzheimer's disease (AD) and Parkinson's …

Historically, the locus coeruleus-norepinephrine (LC-NE) system has been implicated in
arousal, but recent findings suggest that this system plays a more complex and specific role …

It is widely recognized that the neural basis of brain function can be fully understood only by
integrating many disciplines at many levels. Studies of synaptic organization are bringing …

▪ Abstract Many neurons in the mammalian central nervous system communicate through
electrical synapses, defined here as gap junction–mediated connections. Electrical …

Among the 20 proposed members of the connexin family of proteins that form gap junctional
intercellular communication (GJIC) channels in mammalian tissues, over half are reported to …

Electrical and chemical synapses exist within the same networks of inhibitory cells, and each
kind of synapse is known to be able to foster synchrony among oscillating neurons. Using …