Colorectal cancer is the third most common cancer worldwide with a high mortality rate at
the advanced stages. However, colorectal cancer is not a single type of tumor; its …

Critical driver genomic events in colorectal cancer have been shown to affect the response
to targeted agents that were initially developed under the'one gene, one drug'paradigm of …

This selection from the NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines)
for Colon Cancer focuses on systemic therapy options for the treatment of metastatic …

Background There is increasing evidence that metastatic colorectal cancer (mCRC) is a
genetically heterogeneous disease and that tumours arising from different sides of the colon …

This portion of the NCCN Guidelines for Colon Cancer focuses on the use of systemic
therapy in metastatic disease. Considerations for treatment selection among 32 different …

Aberrant activation of the epidermal growth factor receptor (EGFR/ERBB1) by erythroblastic
leukemia viral oncogene homolog (ERBB) ligands contributes to various tumor …

Importance Primary tumor location is emerging as an important prognostic factor owing to
distinct biological features. However, the side of origin of colon cancer (CC) still does not …

Importance Metastatic colorectal cancer (mCRC) is heterogeneous, and primary tumors
arising from different regions of the colon are clinically and molecularly distinct. Objective To …

Background Retrospective subgroup analyses suggest that primary tumour location (PTL)
has a prognostic importance and relates to response to targeted therapy. Methods We …

Purpose: Colorectal cancers are classified as right/left-sided based on whether they occur
before/after the splenic flexure, with established differences in molecular subtypes and …