Sepsis is a life-threatening condition and a global disease burden. Today, the
heterogeneous syndrome is defined as severe organ dysfunction caused by a dysregulated …

Background Bacteria are the main pathogens that cause sepsis. The pathogenic
mechanisms of sepsis caused by gram-negative and gram-positive bacteria are completely …

Dysregulation of the immune response to bacterial infection can lead to sepsis, a condition
with high mortality. Multiple whole-blood gene-expression studies have defined sepsis …

Pathogenic inflammation and immuno-suppression are cardinal features of exhausted
monocytes increasingly recognized in septic patients and murine models of sepsis …

A complicated clinical course for critically ill patients admitted to the intensive care unit (ICU)
usually includes multiorgan dysfunction and subsequent death. Owing to the heterogeneity …

To utilize metabolomics in conjunction with RNA sequencing to identify biomarkers in the
blood of sepsis patients and discover novel targets for diagnosing and treating sepsis. In …

Objective. Gram‐negative bloodstream infections (GNBSIs), especially those caused by
antibiotic‐resistant species, have become a public health challenge. Procalcitonin (PCT) …

Sepsis is a life-threatening disease induced by a systemic inflammatory response, which
leads to organ dysfunction and mortality. In sepsis, the host immune response is depressed …

Objectives: To derive and validate a predictive algorithm integrating a nomogram-based
prediction of the pretest probability of infection with a panel of serum biomarkers, which …

Purpose Sepsis, with life-threatening organ failure, is caused by the uncontrolled host
response to infection. Immune response plays an important role in the pathophysiology of …