Circular RNAs (circRNAs) are novel clusters of endogenous noncoding RNAs (ncRNAs) that
are widely expressed in eukaryotic cells. In contrast to the generation of linear RNA …

Recent work has provided new insights into how altered B cell-intrinsic signals—through the
B cell receptor (BCR) and key co-receptors—function together to promote the pathogenesis …

Abstract Patients with Wiskott–Aldrich syndrome (WAS) lacking a human leukocyte antigen-
matched donor may benefit from gene therapy through the provision of gene-corrected …

Cellular circular RNAs (circRNAs) are generated by head-to-tail splicing and are present in
all multicellular organisms studied so far. Recently, circRNAs have emerged as a large class …

Summary Background Wiskott-Aldrich syndrome is a rare, life-threatening, X-linked primary
immunodeficiency characterised by microthrombocytopenia, infections, eczema …

Abstract The Wiskott-Aldrich syndrome (WAS) is a rare X-linked disorder originally described
by Dr. Alfred Wiskott in 1937 and Dr. Robert Aldrich in 1954 as a familial disease …

Ras homology (RHO) GTPases are signalling proteins that have crucial roles in triggering
multiple immune functions. Through their interactions with a broad range of effectors and …

The introduction of high throughput sequencing (HTS) techniques greatly improved the
knowledge of inherited thrombocytopenias (ITs) over the last few years. A total of 33 different …

FOXP3 gene is a key transcription factor driving immune tolerance and its deficiency causes
immune dysregulation, polyendocrinopathy, enteropathy X‐linked syndrome (IPEX), a …

Autoimmune regulator (AIRE) mutations result in autoimmune polyendocrinopathy-
candidiasis-ectodermal dystrophy (APECED) syndrome characterized by defective central T …