PIWI-interacting RNAs (piRNAs) are a class of small non-coding RNAs that associate with
proteins of the PIWI clade of the Argonaute family. First identified in animal germ line cells …

The polarized phenotype of the retinal pigment epithelium is crucial for the outer retina-
blood barrier and support of photoreceptors and underlying choroid, and its disruption plays …

PIWI proteins and piRNAs primarily functions as a safeguard of germline cells by activating
epigenetic regulations, silencing transposons and maintaining chromatin structure …

Abstract Background The microRNAs (miRNA) have been found to play an important role in
the pathogenesis of diabetic retinopathy. We try to explore the miRNA and piwi‐interacting …

The Alu element, the most abundant transposable element, is transcribed to Alu RNA. We
hypothesized that the PIWI protein regulates the expression of Alu RNA in retinal pigment …

Diabetic retinopathy (DR) is one of the major causes of blindness resulting from prolonged
hyperglycemia which leads to breakdown of blood retinal barrier and excessive …

PIWI-interacting RNAs (piRNAs), a class of small non-coding RNAs (sncRNAs) with 24–32
nucleotides (nt), were initially identified in the reproductive system. Unlike microRNAs …

Retinoblastoma (RB), a childhood cancer, is caused by biallelic mutation of the RB1 gene,
but its development is not clearly understood. Furthermore, the presence of a cancer stem …

Simple Summary The PIWI-piRNA ribonucleoproteic complexes are pivotal regulators of
genome integrity, differentiation and homeostasis and their dysregulation has recently been …

Long considered active only in the germline, the PIWI/piRNA pathway is now known to play
a significant role in somatic cells, especially neurons. In this study, piRNAs were profiled in …