Marine toxins targeting Kv1 channels: pharmacological tools and therapeutic scaffolds
Toxins from marine animals provide molecular tools for the study of many ion channels,
including mammalian voltage-gated potassium channels of the Kv1 family. Selectivity …
including mammalian voltage-gated potassium channels of the Kv1 family. Selectivity …
Cardiovascular drugs and osteoarthritis: effects of targeting ion channels
Osteoarthritis (OA) and cardiovascular diseases (CVD) share many similar features,
including similar risk factors and molecular mechanisms. A great number of cardiovascular …
including similar risk factors and molecular mechanisms. A great number of cardiovascular …
Mechanism of C-type inactivation in the hERG potassium channel
The fast C-type inactivation displayed by the voltage-activated potassium channel hERG
plays a critical role in the repolarization of cardiac cells, and malfunction caused by …
plays a critical role in the repolarization of cardiac cells, and malfunction caused by …
Modern venomics—Current insights, novel methods, and future perspectives in biological and applied animal venom research
BM von Reumont, G Anderluh, A Antunes… - …, 2022 - academic.oup.com
Venoms have evolved> 100 times in all major animal groups, and their components, known
as toxins, have been fine-tuned over millions of years into highly effective biochemical …
as toxins, have been fine-tuned over millions of years into highly effective biochemical …
Cryo-EM structures of Kv1. 2 potassium channels, conducting and non-conducting
Y Wu, Y Yan, Y Yang, S Bian, A Rivetta, K Allen… - …, 2024 - pmc.ncbi.nlm.nih.gov
We present near-atomic-resolution cryo-EM structures of the mammalian voltage-gated
potassium channel Kv1. 2 in open, C-type inactivated, toxin-blocked and sodium-bound …
potassium channel Kv1. 2 in open, C-type inactivated, toxin-blocked and sodium-bound …
Contributions of natural products to ion channel pharmacology
S Bajaj, ST Ong, KG Chandy - Natural Product Reports, 2020 - pubs.rsc.org
Covering: Up to 2020 Ion channels are a vast super-family of membrane proteins that play
critical physiological roles in excitable and non-excitable cells. Their biomedical importance …
critical physiological roles in excitable and non-excitable cells. Their biomedical importance …
Extracellular modulation of TREK-2 activity with nanobodies provides insight into the mechanisms of K2P channel regulation
KEJ Rödström, A Cloake, J Sörmann… - Nature …, 2024 - nature.com
Potassium channels of the Two-Pore Domain (K2P) subfamily, KCNK1-KCNK18, play
crucial roles in controlling the electrical activity of many different cell types and represent …
crucial roles in controlling the electrical activity of many different cell types and represent …
Voltage-gated K+ Channel Modulation by Marine toxins: pharmacological innovations and Therapeutic opportunities
R Turcio, F Di Matteo, I Capolupo, T Ciaglia… - Marine …, 2024 - pmc.ncbi.nlm.nih.gov
Bioactive compounds are abundant in animals originating from marine ecosystems. Ion
channels, which include sodium, potassium, calcium, and chloride, together with their …
channels, which include sodium, potassium, calcium, and chloride, together with their …
Cyclodextrins Exert a Ligand-like Current Inhibitory Effect on the KV1.3 Ion Channel Independent of Membrane Cholesterol Extraction
Cyclodextrins (CDs) are cyclic oligosaccharides capable of forming water-soluble
complexes with a variety of otherwise poorly soluble molecules including cholesterol and …
complexes with a variety of otherwise poorly soluble molecules including cholesterol and …
Cm28, a scorpion toxin having a unique primary structure, inhibits KV1.2 and KV1.3 with high affinity
MU Naseem, E Carcamo-Noriega… - Journal of General …, 2022 - rupress.org
The Cm28 in the venom of Centruroides margaritatus is a short peptide consisting of 27
amino acid residues with a mol wt of 2,820 D. Cm28 has< 40% similarity with other known α …
amino acid residues with a mol wt of 2,820 D. Cm28 has< 40% similarity with other known α …