Historical DNA (hDNA), obtained from museum and herbarium specimens, has yielded
spectacular new insights into the history of organisms. This includes documenting historical …

In a European BIOMED-2 collaborative study, multiplex PCR assays have successfully been
developed and standardized for the detection of clonally rearranged immunoglobulin (Ig) …

Context Formalin fixation and paraffin embedding is a timeless, cost-efficient, and widely
adopted method of preserving human tissue biospecimens that has resulted in a substantial …

qRT-PCR (real-time reverse transcription-PCR) has become the benchmark for the detection
and quantification of RNA targets and is being utilized increasingly in novel clinical …

Purpose We sought to determine the prevalence of biologically relevant human
papillomavirus (HPV) in oropharyngeal squamous cell carcinoma (OSCC). Retinoblastoma …

Background & Aims: Sporadic colorectal cancers with a high degree of microsatellite
instability are a clinically distinct subgroup with a high incidence of BRAF mutation and are …

As a review for the 20th anniversary of publishing the antigen retrieval (AR) technique in this
journal, the authors intend briefly to summarize developments in AR-immunohistochemistry …

Development of the antigen retrieval (AR) technique, a simple method of boiling archival
paraffin-embedded tissue sections in water to enhance the signal of immunohistochemistry …

Angiogenesis and lymphangiogenesis are essential for breast cancer progression and are
regulated by vascular endothelial growth factors (VEGF). To determine clinical and …

The histopathology archive represents a vast, well‐characterized source of specimens
covering virtually every disease and is available for molecular biological investigation. The …