Targeting adipose tissue in the treatment of obesity-associated diabetes

CM Kusminski, PE Bickel, PE Scherer - Nature reviews Drug discovery, 2016 - nature.com
Adipose tissue regulates numerous physiological processes, and its dysfunction in obese
humans is associated with disrupted metabolic homeostasis, insulin resistance and type 2 …

Brown adipose tissue energy metabolism in humans

AC Carpentier, DP Blondin, KA Virtanen… - Frontiers in …, 2018 - frontiersin.org
The demonstration of metabolically active brown adipose tissue (BAT) in humans primarily
using positron emission tomography coupled to computed tomography (PET/CT) with the …

Magnetic resonance imaging techniques for brown adipose tissue detection

M Wu, D Junker, RT Branca… - Frontiers in …, 2020 - frontiersin.org
Magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS) methods
can non-invasively assess brown adipose tissue (BAT) structure and function. Recently, MRI …

Recent advances in the detection of brown adipose tissue in adult humans: a review

FJ Ong, BA Ahmed, SM Oreskovich, DP Blondin… - Clinical …, 2018 - portlandpress.com
The activation of brown adipose tissue (BAT) is associated with reductions in circulating
lipids and glucose in rodents and contributes to energy expenditure in humans indicating …

Assessment of human brown adipose tissue density during daily ingestion of thermogenic capsinoids using near-infrared time-resolved spectroscopy

S Nirengi, T Homma, N Inoue, H Sato… - … of biomedical optics, 2016 - spiedigitallibrary.org
F 18-fluorodeoxyglucose positron emission tomography combined with computed
tomography (FDG-PET/CT) is widely used as a standard method for evaluating human …

Non‐invasive methods for the assessment of brown adipose tissue in humans

M Chondronikola, SC Beeman… - The Journal of …, 2018 - Wiley Online Library
Brown adipose tissue (BAT) is a recently rediscovered tissue in people that has shown
promise as a potential therapeutic target against obesity and its metabolic abnormalities …

In-vivo detection of white adipose tissue browning: a multimodality imaging approach

LR Holmes, JC Garside, J Frank, E Livingston… - Scientific Reports, 2023 - nature.com
Detection and differentiation of brown fat in humans poses several challenges, as this tissue
is sparse and often mixed with white adipose tissue. Non-invasive detection of beige fat …

Molecular imaging of brown adipose tissue mass

J Yang, H Zhang, K Parhat, H Xu, M Li, X Wang… - International Journal of …, 2021 - mdpi.com
Brown adipose tissue (BAT), a uniquely thermogenic tissue that plays an important role in
metabolism and energy expenditure, has recently become a revived target in the fight …

In vivo assessment of cold stimulation effects on the fat fraction of brown adipose tissue using DIXON MRI

V Stahl, F Maier, MT Freitag, RO Floca… - Journal of Magnetic …, 2017 - Wiley Online Library
Purpose To evaluate the volume and changes of human brown adipose tissue (BAT) in vivo
following exposure to cold using magnetic resonance imaging (MRI). Materials and Methods …

Supraclavicular brown adipose tissue 18F-FDG uptake and cardiovascular disease

RAP Takx, A Ishai, QA Truong… - Journal of Nuclear …, 2016 - Soc Nuclear Med
Preclinical data suggest a negative correlation between brown adipose tissue (BAT) and the
degree of coronary atherosclerosis. We sought to evaluate the relationship between 18F …