The roles of histone deacetylases and their inhibitors in cancer therapy
G Li, Y Tian, WG Zhu - Frontiers in cell and developmental biology, 2020 - frontiersin.org
Genetic mutations and abnormal gene regulation are key mechanisms underlying
tumorigenesis. Nucleosomes, which consist of DNA wrapped around histone cores …
tumorigenesis. Nucleosomes, which consist of DNA wrapped around histone cores …
Targeting protein modifications in metabolic diseases: molecular mechanisms and targeted therapies
The ever-increasing prevalence of noncommunicable diseases (NCDs) represents a major
public health burden worldwide. The most common form of NCD is metabolic diseases …
public health burden worldwide. The most common form of NCD is metabolic diseases …
Aberrant cholesterol metabolic signaling impairs antitumor immunosurveillance through natural killer T cell dysfunction in obese liver
W Tang, J Zhou, W Yang, Y Feng, H Wu… - Cellular & Molecular …, 2022 - nature.com
Obesity is a major risk factor for cancers including hepatocellular carcinoma (HCC) that
develops from a background of non-alcoholic fatty liver disease (NAFLD) …
develops from a background of non-alcoholic fatty liver disease (NAFLD) …
Regulation and targeting of SREBP-1 in hepatocellular carcinoma
F Su, A Koeberle - Cancer and Metastasis Reviews, 2024 - Springer
Hepatocellular carcinoma (HCC) is an increasing burden on global public health and is
associated with enhanced lipogenesis, fatty acid uptake, and lipid metabolic …
associated with enhanced lipogenesis, fatty acid uptake, and lipid metabolic …
Targeting SREBP-1-mediated lipogenesis as potential strategies for cancer
Q Zhao, X Lin, G Wang - Frontiers in oncology, 2022 - frontiersin.org
Sterol regulatory element binding protein-1 (SREBP-1), a transcription factor with a basic
helix–loop–helix leucine zipper, has two isoforms, SREBP-1a and SREBP-1c, derived from …
helix–loop–helix leucine zipper, has two isoforms, SREBP-1a and SREBP-1c, derived from …
Cytoplasmic SIRT6-mediated ACSL5 deacetylation impedes nonalcoholic fatty liver disease by facilitating hepatic fatty acid oxidation
Nonalcoholic fatty liver disease (NAFLD) is characterized by excessive hepatic lipid
accumulation, which can progress to nonalcoholic steatohepatitis (NASH). Histone …
accumulation, which can progress to nonalcoholic steatohepatitis (NASH). Histone …
Lipid metabolism in development and progression of hepatocellular carcinoma
Metabolic reprogramming is critically involved in the development and progression of
cancer. In particular, lipid metabolism has been investigated as a source of energy, micro …
cancer. In particular, lipid metabolism has been investigated as a source of energy, micro …
A selective HDAC8 inhibitor potentiates antitumor immunity and efficacy of immune checkpoint blockade in hepatocellular carcinoma
Insufficient T cell infiltration into noninflamed tumors, such as hepatocellular carcinoma
(HCC), restricts the effectiveness of immune-checkpoint blockade (ICB) for a subset of …
(HCC), restricts the effectiveness of immune-checkpoint blockade (ICB) for a subset of …
Epidemiologic, genetic, pathogenic, metabolic, epigenetic aspects involved in NASH-HCC: current therapeutic strategies
J Gutiérrez-Cuevas, S Lucano-Landeros… - Cancers, 2022 - mdpi.com
Simple Summary Hepatocellular carcinoma (HCC) is an aggressive human cancer and is
caused as consequences of chronic liver diseases. Although HCC is more common in …
caused as consequences of chronic liver diseases. Although HCC is more common in …
Wnt/β-catenin signaling in liver cancers
W Wang, R Smits, H Hao, C He - Cancers, 2019 - mdpi.com
Liver cancer is among the leading global healthcare issues associated with high morbidity
and mortality. Liver cancer consists of hepatocellular carcinoma (HCC), cholangiocarcinoma …
and mortality. Liver cancer consists of hepatocellular carcinoma (HCC), cholangiocarcinoma …