[HTML][HTML] mTOR substrate phosphorylation in growth control
The target of rapamycin (TOR), discovered 30 years ago, is a highly conserved
serine/threonine protein kinase that plays a central role in regulating cell growth and …
serine/threonine protein kinase that plays a central role in regulating cell growth and …
mTOR complex 2 signaling and functions
WJ Oh, E Jacinto - Cell cycle, 2011 - Taylor & Francis
The mechanistic target of rapamycin (mTOR) plays a central role in cellular growth and
metabolism. mTOR forms two distinct protein complexes, mTORC1 and mTORC2. Much is …
metabolism. mTOR forms two distinct protein complexes, mTORC1 and mTORC2. Much is …
mTORC1 phosphorylation sites encode their sensitivity to starvation and rapamycin
Introduction The mechanistic target of rapamycin (mTOR) complex 1 (mTORC1) protein
kinase promotes cell growth by controlling major anabolic and catabolic processes in …
kinase promotes cell growth by controlling major anabolic and catabolic processes in …
Probing cellular protein complexes using single-molecule pull-down
Proteins perform most cellular functions in macromolecular complexes. The same protein
often participates in different complexes to exhibit diverse functionality. Current ensemble …
often participates in different complexes to exhibit diverse functionality. Current ensemble …
The role of the mammalian target of rapamycin (mTOR) in pulmonary fibrosis
J Lawrence, R Nho - International journal of molecular sciences, 2018 - mdpi.com
The phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT)/mammalian target of
rapamycin (mTOR)-dependent pathway is one of the most integral pathways linked to cell …
rapamycin (mTOR)-dependent pathway is one of the most integral pathways linked to cell …
[HTML][HTML] Nutrient regulation of the mTOR complex 1 signaling pathway
The mammalian target of rapamycin (mTOR) is an evolutionally conserved kinase which
exists in two distinct structural and functional complexes, mTOR complex 1 (mTORC1) and …
exists in two distinct structural and functional complexes, mTOR complex 1 (mTORC1) and …
The enterococcal cytolysin synthetase has an unanticipated lipid kinase fold
The enterococcal cytolysin is a virulence factor consisting of two post-translationally
modified peptides that synergistically kill human immune cells. Both peptides are made by …
modified peptides that synergistically kill human immune cells. Both peptides are made by …
Mammalian TOR signaling to the AGC kinases
B Su, E Jacinto - Critical reviews in biochemistry and molecular …, 2011 - Taylor & Francis
The mechanistic (or mammalian) target of rapamycin (mTOR), an evolutionarily conserved
protein kinase, orchestrates cellular responses to growth, metabolic and stress signals …
protein kinase, orchestrates cellular responses to growth, metabolic and stress signals …
Stoichiometry and assembly of mTOR complexes revealed by single-molecule pulldown
The mammalian target of rapamycin (mTOR) kinase is a master regulator of cellular,
developmental, and metabolic processes. Deregulation of mTOR signaling is implicated in …
developmental, and metabolic processes. Deregulation of mTOR signaling is implicated in …
[HTML][HTML] mTOR complex-2 stimulates acetyl-CoA and de novo lipogenesis through ATP citrate lyase in HER2/PIK3CA-hyperactive breast cancer
Y Chen, J Qian, Q He, H Zhao, L Toral-Barza, C Shi… - Oncotarget, 2016 - ncbi.nlm.nih.gov
The mechanistic target of rapamycin (mTOR) is a major regulator of cell growth and is
frequently dysregulated in cancer. While mTOR complex-1 (mTORC1) is a validated cancer …
frequently dysregulated in cancer. While mTOR complex-1 (mTORC1) is a validated cancer …