Epilepsy is a chronic neurologic disorder that affects over 70 million people worldwide.
Despite the availability of over 20 antiseizure drugs (ASDs) for symptomatic treatment of …

Antiepileptic drugs (AEDs) provide satisfactory control of seizures for most patients with
epilepsy. The drugs have the remarkable ability to protect against seizures while permitting …

This review focuses on the remodeling of brain circuitry associated with epilepsy, particularly
in excitatory glutamate and inhibitory GABA systems, including alterations in synaptic …

Drug‐resistant epilepsy with uncontrolled severe seizures despite state‐of‐the‐art medical
treatment continues to be a major clinical problem for up to one in three patients with …

Epilepsy is a common and devastating neurological disorder. In many patients with epilepsy,
seizures are well-controlled with currently available anti-epileptic drugs (AEDs), but a …

Epileptogenesis refers to a process in which an initial brain-damaging insult triggers a
cascade of molecular and cellular changes that eventually lead to the occurrence of …

In many patients who suffer from epilepsies, recurrent epileptic seizures do not start at birth
but develop later in life. This holds particularly true for epilepsies with a focal seizure origin …

Antiepileptic drugs (AEDs) are commonly prescribed for nonepileptic conditions, including
migraine headache, chronic neuropathic pain, mood disorders, schizophrenia and various …

During the past several years, there has been increasing interest in the role of the blood–
brain barrier (BBB) in epilepsy. Advances in neuroradiology have enhanced our ability to …

Epileptogenesis refers to a phenomenon in which the brain undergoes molecular and
cellular alterations after a brain‐damaging insult, which increase its excitability and …